| Title |
Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia
|
|---|---|
| Published in |
British Journal of Cancer, August 2016
|
| DOI | 10.1038/bjc.2016.261 |
| Pubmed ID | |
| Authors |
G Bogdanovic, C Pou, M Barrientos-Somarribas, A Bjerkner, E Honkaniemi, T Allander, B Andersson, B Gustafsson |
| Abstract |
Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in the first pre-leukaemic clone development. The DNA virome of 95 children who later developed ALL was characterised from neonatal blood spots (NBS) using unbiased next-generation sequencing (NGS) and compared with the virome of 95 non-ALL controls. DNA was individually extracted from the ALL-patients and controls, pooled, randomly amplified and sequenced using the Illumina MiSeq Sequencing System. Virus-like sequences identified in both groups mapped to human endogenous retroviruses and propionibacterium phage, considered a part of the normal microbial flora. Potential pathogens human herpesvirus type 6 (HHV-6) and parvovirus B19 were also identified, but only few samples in both ALL and controls tested positive by PCR follow-up. Unbiased NGS was employed to search for DNA from potential infectious agents in neonatal samples of children who later developed ALL. Although several viral candidates were identified in the NBS samples, further investigation by PCR suggested that these viruses did not have a major role in ALL development.British Journal of Cancer advance online publication, 23 August 2016; doi:10.1038/bjc.2016.261 www.bjcancer.com. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 20% |
| Sweden | 1 | 20% |
| Germany | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 19% |
| Student > Ph. D. Student | 7 | 17% |
| Researcher | 7 | 17% |
| Student > Master | 5 | 12% |
| Unspecified | 2 | 5% |
| Other | 7 | 17% |
| Unknown | 6 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 26% |
| Medicine and Dentistry | 8 | 19% |
| Agricultural and Biological Sciences | 7 | 17% |
| Unspecified | 2 | 5% |
| Immunology and Microbiology | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 9 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2017.
All research outputs
#14,269,564
of 22,883,326 outputs
Outputs from British Journal of Cancer
#8,879
of 10,439 outputs
Outputs of similar age
#197,742
of 342,845 outputs
Outputs of similar age from British Journal of Cancer
#85
of 98 outputs
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