| Title |
The ovarian cancer oncobiome
|
|---|---|
| Published in |
Oncotarget, March 2017
|
| DOI | 10.18632/oncotarget.16717 |
| Pubmed ID | |
| Authors |
Sagarika Banerjee, Tian Tian, Zhi Wei, Natalie Shih, Michael D. Feldman, James C. Alwine, George Coukos, Erle S. Robertson |
| Abstract |
Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have identified a microbiome signature unique to ovarian cancers, one of the most lethal malignancies of the female reproductive system, primarily because of its asymptomatic nature during the early stages in development. We screened ovarian cancer samples along with matched, and non-matched control samples using our pan-pathogen array (PathoChip), combined with capture-next generation sequencing. The results show a distinct group of viral, bacterial, fungal and parasitic signatures of high significance in ovarian cases. Further analysis shows specific viral integration sites within the host genome of tumor samples, which may contribute to the carcinogenic process. The ovarian cancer microbiome signature provides insights for the development of targeted therapeutics against ovarian cancers. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 46% |
| Chile | 1 | 4% |
| Portugal | 1 | 4% |
| Canada | 1 | 4% |
| Unknown | 12 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 75% |
| Scientists | 6 | 21% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 154 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 18% |
| Student > Ph. D. Student | 22 | 14% |
| Student > Master | 12 | 8% |
| Student > Bachelor | 12 | 8% |
| Student > Doctoral Student | 9 | 6% |
| Other | 28 | 18% |
| Unknown | 44 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 18% |
| Medicine and Dentistry | 21 | 14% |
| Agricultural and Biological Sciences | 16 | 10% |
| Immunology and Microbiology | 14 | 9% |
| Engineering | 2 | 1% |
| Other | 13 | 8% |
| Unknown | 61 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2022.
All research outputs
#1,172,102
of 25,388,177 outputs
Outputs from Oncotarget
#545
of 14,308 outputs
Outputs of similar age
#23,354
of 323,187 outputs
Outputs of similar age from Oncotarget
#34
of 1,459 outputs
Altmetric has tracked 25,388,177 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,308 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1,459 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.