| Title |
Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development
|
|---|---|
| Published in |
PLoS Pathogens, July 2017
|
| DOI | 10.1371/journal.ppat.1006440 |
| Pubmed ID | |
| Authors |
Ritesh Kumar, Jennifer L. Herold, Deborah Schady, Jennifer Davis, Scott Kopetz, Margarita Martinez-Moczygemba, Barbara E. Murray, Fang Han, Yu Li, Evelyn Callaway, Robert S. Chapkin, Wan-Mohaiza Dashwood, Roderick H. Dashwood, Tia Berry, Chris Mackenzie, Yi Xu |
| Abstract |
Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong association with colorectal cancer (CRC). This knowledge has important clinical implications, and yet little is known about the role of Sg in the development of CRC. Here we demonstrate that Sg promotes human colon cancer cell proliferation in a manner that depends on cell context, bacterial growth phase and direct contact between bacteria and colon cancer cells. In addition, we observed increased level of β-catenin, c-Myc and PCNA in colon cancer cells following incubation with Sg. Knockdown or inhibition of β-catenin abolished the effect of Sg. Furthermore, mice administered with Sg had significantly more tumors, higher tumor burden and dysplasia grade, and increased cell proliferation and β-catenin staining in colonic crypts compared to mice receiving control bacteria. Finally, we showed that Sg is present in the majority of CRC patients and is preferentially associated with tumor compared to normal tissues obtained from CRC patients. These results taken together establish for the first time a tumor-promoting role of Sg that involves specific bacterial and host factors and have important clinical implications. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 41% |
| United Kingdom | 4 | 9% |
| Ireland | 2 | 5% |
| Spain | 1 | 2% |
| Italy | 1 | 2% |
| Canada | 1 | 2% |
| Poland | 1 | 2% |
| France | 1 | 2% |
| Malaysia | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 14 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 59% |
| Scientists | 11 | 25% |
| Practitioners (doctors, other healthcare professionals) | 5 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 123 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 19% |
| Student > Ph. D. Student | 15 | 12% |
| Researcher | 15 | 12% |
| Student > Master | 12 | 10% |
| Professor | 6 | 5% |
| Other | 24 | 20% |
| Unknown | 28 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 24% |
| Medicine and Dentistry | 26 | 21% |
| Agricultural and Biological Sciences | 13 | 11% |
| Immunology and Microbiology | 10 | 8% |
| Unspecified | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 33 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 172. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2023.
All research outputs
#238,961
of 25,734,859 outputs
Outputs from PLoS Pathogens
#154
of 9,538 outputs
Outputs of similar age
#4,985
of 325,599 outputs
Outputs of similar age from PLoS Pathogens
#3
of 173 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,599 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 173 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.