| Title |
Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use
|
|---|---|
| Published in |
PLoS Pathogens, November 2017
|
| DOI | 10.1371/journal.ppat.1006653 |
| Pubmed ID | |
| Authors |
Bryony N. Parsons, Umer Z. Ijaz, Rosalinda D’Amore, Michael D. Burkitt, Richard Eccles, Luca Lenzi, Carrie A. Duckworth, Andrew R. Moore, Laszlo Tiszlavicz, Andrea Varro, Neil Hall, D. Mark Pritchard |
| Abstract |
Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each of these conditions was associated with specific alterations in the gastric microbiota and that this influenced subsequent tumour risk. 95 patients (in groups representing normal stomach, PPI treated, H. pylori gastritis, H. pylori-induced atrophic gastritis and autoimmune atrophic gastritis) were selected from a cohort of 1400. RNA extracted from gastric corpus biopsies was analysed using 16S rRNA sequencing (MiSeq). Samples from normal stomachs and patients treated with PPIs demonstrated similarly high microbial diversity. Patients with autoimmune atrophic gastritis also exhibited relatively high microbial diversity, but with samples dominated by Streptococcus. H. pylori colonisation was associated with decreased microbial diversity and reduced complexity of co-occurrence networks. H. pylori-induced atrophic gastritis resulted in lower bacterial abundances and diversity, whereas autoimmune atrophic gastritis resulted in greater bacterial abundance and equally high diversity compared to normal stomachs. Pathway analysis suggested that glucose-6-phospahte1-dehydrogenase and D-lactate dehydrogenase were over represented in H. pylori-induced atrophic gastritis versus autoimmune atrophic gastritis, and that both these groups showed increases in fumarate reductase. Autoimmune and H. pylori-induced atrophic gastritis were associated with different gastric microbial profiles. PPI treated patients showed relatively few alterations in the gastric microbiota compared to healthy subjects. |
X Demographics
The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 7 | 18% |
| United States | 6 | 15% |
| Spain | 2 | 5% |
| Switzerland | 1 | 3% |
| Thailand | 1 | 3% |
| Australia | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Greece | 1 | 3% |
| Unknown | 20 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 55% |
| Scientists | 14 | 35% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 180 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 180 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 13% |
| Student > Master | 23 | 13% |
| Student > Bachelor | 20 | 11% |
| Student > Ph. D. Student | 19 | 11% |
| Student > Doctoral Student | 9 | 5% |
| Other | 28 | 16% |
| Unknown | 57 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 23% |
| Biochemistry, Genetics and Molecular Biology | 17 | 9% |
| Agricultural and Biological Sciences | 16 | 9% |
| Immunology and Microbiology | 11 | 6% |
| Nursing and Health Professions | 9 | 5% |
| Other | 23 | 13% |
| Unknown | 62 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 81. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2018.
All research outputs
#528,184
of 25,411,814 outputs
Outputs from PLoS Pathogens
#408
of 9,480 outputs
Outputs of similar age
#11,308
of 340,941 outputs
Outputs of similar age from PLoS Pathogens
#13
of 143 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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