| Title |
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
|
|---|---|
| Published in |
Science, November 2017
|
| DOI | 10.1126/science.aan3706 |
| Pubmed ID | |
| Authors |
Bertrand Routy, Emmanuelle Le Chatelier, Lisa Derosa, Connie P M Duong, Maryam Tidjani Alou, Romain Daillère, Aurélie Fluckiger, Meriem Messaoudene, Conrad Rauber, Maria P Roberti, Marine Fidelle, Caroline Flament, Vichnou Poirier-Colame, Paule Opolon, Christophe Klein, Kristina Iribarren, Laura Mondragón, Nicolas Jacquelot, Bo Qu, Gladys Ferrere, Céline Clémenson, Laura Mezquita, Jordi Remon Masip, Charles Naltet, Solenn Brosseau, Coureche Kaderbhai, Corentin Richard, Hira Rizvi, Florence Levenez, Nathalie Galleron, Benoit Quinquis, Nicolas Pons, Bernhard Ryffel, Véronique Minard-Colin, Patrick Gonin, Jean-Charles Soria, Eric Deutsch, Yohann Loriot, François Ghiringhelli, Gérard Zalcman, François Goldwasser, Bernard Escudier, Matthew D Hellmann, Alexander Eggermont, Didier Raoult, Laurence Albiges, Guido Kroemer, Laurence Zitvogel |
| Abstract |
Immune checkpoint inhibitors (ICI) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizeable minority of cancer patients. Here, we show that primary resistance to ICI can be due to abnormal gut microbiome composition. Antibiotics (ATB) inhibited the clinical benefit of ICI in patients with advanced cancer. Fecal microbiota transplantation (FMT) from cancer patients who responded to ICI (but not from non-responding patients) into germ-free or ATB-treated mice ameliorated the antitumor effects of PD-1 blockade. Metagenomics of patient stools at diagnosis revealed correlations between clinical responses to ICI and the relative abundance of Akkermansia muciniphila Oral supplementation with A. muciniphila post-FMT with non-responder feces restored the efficacy of PD-1 blockade in an IL-12-dependent manner, by increasing the recruitment of CCR9(+)CXCR3(+)CD4(+) T lymphocytes into tumor beds. |
X Demographics
The data shown below were collected from the profiles of 789 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 204 | 26% |
| Spain | 58 | 7% |
| United Kingdom | 53 | 7% |
| France | 28 | 4% |
| Australia | 21 | 3% |
| Canada | 17 | 2% |
| Italy | 13 | 2% |
| Germany | 9 | 1% |
| Brazil | 8 | 1% |
| Other | 97 | 12% |
| Unknown | 281 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 462 | 59% |
| Scientists | 224 | 28% |
| Practitioners (doctors, other healthcare professionals) | 82 | 10% |
| Science communicators (journalists, bloggers, editors) | 21 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 3,188 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3188 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 564 | 18% |
| Student > Ph. D. Student | 434 | 14% |
| Student > Bachelor | 295 | 9% |
| Student > Master | 291 | 9% |
| Other | 187 | 6% |
| Other | 482 | 15% |
| Unknown | 935 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 567 | 18% |
| Medicine and Dentistry | 505 | 16% |
| Immunology and Microbiology | 352 | 11% |
| Agricultural and Biological Sciences | 339 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 91 | 3% |
| Other | 271 | 9% |
| Unknown | 1063 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1380. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#9,350
of 25,824,818 outputs
Outputs from Science
#480
of 83,326 outputs
Outputs of similar age
#140
of 342,127 outputs
Outputs of similar age from Science
#5
of 1,310 outputs
Altmetric has tracked 25,824,818 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,326 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.1. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 1,310 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.