Title |
The participation of cortical amygdala in innate, odour-driven behaviour
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Published in |
Nature, November 2014
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DOI | 10.1038/nature13897 |
Pubmed ID | |
Authors |
Cory M. Root, Christine A. Denny, René Hen, Richard Axel |
Abstract |
Innate behaviours are observed in naive animals without prior learning or experience, suggesting that the neural circuits that mediate these behaviours are genetically determined and stereotyped. The neural circuits that convey olfactory information from the sense organ to the cortical and subcortical olfactory centres have been anatomically defined, but the specific pathways responsible for innate responses to volatile odours have not been identified. Here we devise genetic strategies that demonstrate that a stereotyped neural circuit that transmits information from the olfactory bulb to cortical amygdala is necessary for innate aversive and appetitive behaviours. Moreover, we use the promoter of the activity-dependent gene arc to express the photosensitive ion channel, channelrhodopsin, in neurons of the cortical amygdala activated by odours that elicit innate behaviours. Optical activation of these neurons leads to appropriate behaviours that recapitulate the responses to innate odours. These data indicate that the cortical amygdala plays a critical role in generating innate odour-driven behaviours but do not preclude its participation in learned olfactory behaviours. |
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United States | 7 | 37% |
United Kingdom | 2 | 11% |
Netherlands | 1 | 5% |
Ireland | 1 | 5% |
Canada | 1 | 5% |
Unknown | 7 | 37% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 15 | 79% |
Scientists | 3 | 16% |
Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 16 | 2% |
United Kingdom | 5 | <1% |
Germany | 2 | <1% |
Chile | 2 | <1% |
France | 2 | <1% |
Spain | 2 | <1% |
Japan | 2 | <1% |
Switzerland | 1 | <1% |
Portugal | 1 | <1% |
Other | 7 | <1% |
Unknown | 678 | 94% |
Demographic breakdown
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Researcher | 146 | 20% |
Student > Bachelor | 67 | 9% |
Student > Master | 60 | 8% |
Student > Doctoral Student | 45 | 6% |
Other | 108 | 15% |
Unknown | 111 | 15% |
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Neuroscience | 278 | 39% |
Agricultural and Biological Sciences | 232 | 32% |
Biochemistry, Genetics and Molecular Biology | 23 | 3% |
Medicine and Dentistry | 21 | 3% |
Psychology | 11 | 2% |
Other | 29 | 4% |
Unknown | 124 | 17% |