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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of Cellular Activation on Anti-HIV-1 Restriction Factor Expression Profile in Primary Cells
|
|---|---|
| Published in |
Journal of Virology, August 2013
|
| DOI | 10.1128/jvi.02128-13 |
| Pubmed ID | |
| Authors |
Rui André Saraiva Raposo, Mohamed Abdel-Mohsen, Miroslawa Bilska, David C. Montefiori, Douglas F. Nixon, Satish K. Pillai |
| Abstract |
Expression of cell-intrinsic antiviral factors suppresses HIV-1 replication. We hypothesized that cellular activation modulates host restriction and susceptibility to HIV-1 infection. We measured the gene expression of 34 antiviral factors in healthy peripheral blood mononuclear cells (PBMC). Cellular activation induced expression of interferon-stimulated gene 15 (ISG15), tripartite motif 5α (TRIM5α), bone marrow stromal cell antigen 2 (BST-2)/tetherin, and certain apolipoprotein B mRNA editing enzyme 3 (APOBEC3) family members. Expression of RTF1, RNA polymerase II-associated factor 1 (PAF1), TRIM11, TRIM26, and BST-2/tetherin correlated with decreased HIV-1 infectivity. This report demonstrates synchronous effects of activation-induced antiviral genes on HIV-1 infectivity, providing candidates for pharmacological manipulation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Spain | 1 | 2% |
| India | 1 | 2% |
| Puerto Rico | 1 | 2% |
| Unknown | 52 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 29% |
| Student > Ph. D. Student | 14 | 25% |
| Student > Bachelor | 9 | 16% |
| Student > Master | 4 | 7% |
| Student > Doctoral Student | 3 | 5% |
| Other | 7 | 13% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 32% |
| Biochemistry, Genetics and Molecular Biology | 14 | 25% |
| Medicine and Dentistry | 9 | 16% |
| Immunology and Microbiology | 8 | 14% |
| Engineering | 2 | 4% |
| Other | 0 | 0% |
| Unknown | 5 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2013.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Journal of Virology
#23,560
of 25,691 outputs
Outputs of similar age
#159,374
of 210,379 outputs
Outputs of similar age from Journal of Virology
#153
of 193 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25,691 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,379 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 193 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.