Title |
Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo
|
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Published in |
Journal of Virology, October 2013
|
DOI | 10.1128/jvi.02687-13 |
Pubmed ID | |
Authors |
Mohamed Abdel-Mohsen, Xutao Deng, Teri Liegler, John C. Guatelli, Mohamed S. Salama, Hussam El-din A. Ghanem, Andri Rauch, Bruno Ledergerber, Steven G. Deeks, Huldrych F. Günthard, Joseph K. Wong, Satish K. Pillai |
Abstract |
Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4(+) T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r(2) = 0.649; P < 0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 19% |
Student > Bachelor | 7 | 16% |
Student > Master | 6 | 14% |
Researcher | 5 | 12% |
Student > Doctoral Student | 2 | 5% |
Other | 7 | 16% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 10 | 23% |
Medicine and Dentistry | 9 | 21% |
Agricultural and Biological Sciences | 8 | 19% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Social Sciences | 1 | 2% |
Other | 3 | 7% |
Unknown | 7 | 16% |