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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type
|
|---|---|
| Published in |
Cancer Cell, May 2011
|
| DOI | 10.1016/j.ccr.2011.03.011 |
| Pubmed ID | |
| Authors |
David H. Nguyen, Hellen A. Oketch-Rabah, Irineu Illa-Bochaca, Felipe C. Geyer, Jorge S. Reis-Filho, Jian-Hua Mao, Shraddha A. Ravani, Jiri Zavadil, Alexander D. Borowsky, D. Joseph Jerry, Karen A. Dunphy, Jae Hong Seo, Sandra Haslam, Daniel Medina, Mary Helen Barcellos-Hoff |
| Abstract |
Tissue microenvironment is an important determinant of carcinogenesis. We demonstrate that ionizing radiation, a known carcinogen, affects cancer frequency and characteristics by acting on the microenvironment. Using a mammary chimera model in which an irradiated host is transplanted with oncogenic Trp53 null epithelium, we show accelerated development of aggressive tumors whose molecular signatures were distinct from tumors arising in nonirradiated hosts. Molecular and genetic approaches show that TGFβ mediated tumor acceleration. Tumor molecular signatures implicated TGFβ, and genetically reducing TGFβ abrogated the effect on latency. Surprisingly, tumors from irradiated hosts were predominantly estrogen receptor negative. This effect was TGFβ independent and linked to mammary stem cell activity. Thus, the irradiated microenvironment affects latency and clinically relevant features of cancer through distinct and unexpected mechanisms. |
X Demographics
The data shown below were collected from the profiles of 192 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 67 | 35% |
| Austria | 2 | 1% |
| China | 2 | 1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 117 | 61% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 188 | 98% |
| Scientists | 2 | 1% |
| Practitioners (doctors, other healthcare professionals) | 1 | <1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 4% |
| Japan | 2 | 2% |
| South Africa | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Singapore | 1 | <1% |
| Italy | 1 | <1% |
| New Zealand | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 113 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 37 | 29% |
| Student > Ph. D. Student | 29 | 23% |
| Professor > Associate Professor | 12 | 9% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 8 | 6% |
| Other | 18 | 14% |
| Unknown | 13 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 51 | 40% |
| Biochemistry, Genetics and Molecular Biology | 23 | 18% |
| Medicine and Dentistry | 15 | 12% |
| Engineering | 7 | 5% |
| Physics and Astronomy | 4 | 3% |
| Other | 11 | 9% |
| Unknown | 17 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 144. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2015.
All research outputs
#291,618
of 25,692,343 outputs
Outputs from Cancer Cell
#142
of 3,180 outputs
Outputs of similar age
#951
of 122,668 outputs
Outputs of similar age from Cancer Cell
#1
of 29 outputs
Altmetric has tracked 25,692,343 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,180 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,668 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.