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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Decreased HIV Type 1 Transcription in CCR5-Δ32 Heterozygotes During Suppressive Antiretroviral Therapy
|
|---|---|
| Published in |
Journal of Infectious Diseases, June 2014
|
| DOI | 10.1093/infdis/jiu338 |
| Pubmed ID | |
| Authors |
Charlene Wang, Mohamed Abdel-Mohsen, Matthew C. Strain, Steven M. Lada, Steven Yukl, Leslie R. Cockerham, Christopher D. Pilcher, Frederick M. Hecht, Elizabeth Sinclair, Teri Liegler, Douglas D. Richman, Steven G. Deeks, Satish K. Pillai |
| Abstract |
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P=.013) were significantly lower in CD4+ T cells from CCR5-Δ32 heterozygotes. Cell-associated HIV RNA was significantly correlated with CCR5 surface expression on CD4+ T cells (r2=0.136; P=.002). Our findings suggest that curative strategies should further explore manipulation of CCR5. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 38 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 7 | 18% |
| Student > Ph. D. Student | 6 | 15% |
| Researcher | 6 | 15% |
| Professor > Associate Professor | 4 | 10% |
| Student > Master | 3 | 8% |
| Other | 5 | 13% |
| Unknown | 8 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 28% |
| Medicine and Dentistry | 6 | 15% |
| Immunology and Microbiology | 4 | 10% |
| Engineering | 2 | 5% |
| Social Sciences | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 11 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2015.
All research outputs
#16,048,009
of 25,374,917 outputs
Outputs from Journal of Infectious Diseases
#12,129
of 14,795 outputs
Outputs of similar age
#124,628
of 229,451 outputs
Outputs of similar age from Journal of Infectious Diseases
#61
of 104 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,795 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,451 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.