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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sleep and hypothalamic pituitary adrenal axis responses to metyrapone in posttraumatic stress disorder
|
|---|---|
| Published in |
Psychoneuroendocrinology, December 2017
|
| DOI | 10.1016/j.psyneuen.2017.12.002 |
| Pubmed ID | |
| Authors |
Sabra S. Inslicht, Madhu N. Rao, Anne Richards, Aoife O’Donovan, Carolyn J. Gibson, Tierney Baum, Thomas J. Metzler, Thomas C. Neylan |
| Abstract |
Disturbed sleep is a core feature of posttraumatic stress disorder (PTSD), characterized in part by decreased delta power sleep that may result from stress-related alterations in corticotropin releasing factor (CRF), hypothalamic pituitary adrenal axis (HPA) regulation and glucocorticoid signaling. Overnight HPA axis response mediating sleep disturbances in men and women with PTSD was examined using a metyrapone challenge. Metyrapone blocks cortisol synthesis, removing negative feedback, and increases the release of hypothalamic CRF and pituitary adrenocorticotropic hormone (ACTH). Laboratory-based polysomnography was used to monitor the sleep of 66 medically healthy, medication-free men and pre-menopausal follicular phase women including 33 with chronic PTSD (16 women and 17 men) and 33 age- and sex-matched controls (14 women and 19 men) over 3 consecutive nights. Participants completed an overnight metyrapone challenge after an adaptation and baseline night of sleep and ACTH was obtained by repeated blood sampling. Metyrapone resulted in a greater increase in ACTH and greater decreases in cortisol and delta spectral power sleep in PTSD subjects compared to controls, and a greater increase in ACTH in women compared to men. There was no sex difference in metyrapone effects on delta power sleep, and no significant metyrapone by PTSD by sex interactions with either ACTH or delta power sleep. Regression analyses indicated that a greater increase in ACTH response was associated with a greater decrease in delta power sleep response in PTSD subjects, but no such relationship was found in controls. The PTSD group difference was similar in men and women. These results suggest that stress-related alterations of the HPA axis in PTSD may contribute to sleep difficulties. Therapeutics that target the HPA axis may offer promise as a potential future treatment for PTSD and related sleep difficulties. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 17% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 7 | 12% |
| Researcher | 7 | 12% |
| Student > Doctoral Student | 5 | 8% |
| Other | 7 | 12% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 20% |
| Medicine and Dentistry | 11 | 19% |
| Neuroscience | 9 | 15% |
| Nursing and Health Professions | 2 | 3% |
| Sports and Recreations | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 20 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Psychoneuroendocrinology
#2,822
of 3,906 outputs
Outputs of similar age
#280,117
of 446,047 outputs
Outputs of similar age from Psychoneuroendocrinology
#36
of 55 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,906 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,047 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.