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Glioblastoma

Overview of attention for book
Cover of 'Glioblastoma'

Table of Contents

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    Book Overview
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    Chapter 1 Whole Genome Sequencing-Based Discovery of Structural Variants in Glioblastoma
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    Chapter 2 Whole Genome DNA Methylation Analysis of Human Glioblastoma Using Illumina BeadArrays
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    Chapter 3 Establishing Primary Human Glioblastoma Adherent Cultures from Operative Specimens
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    Chapter 4 Establishing Primary Human Glioblastoma Tumorsphere Cultures from Operative Specimens
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    Chapter 5 Isolation of Glioblastoma Stem Cells with Flow Cytometry
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    Chapter 6 Lentiviral Transduction of Primary Human Glioblastoma Cultures
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    Chapter 7 Selective Targeting of CD133-Expressing Glioblastoma Stem Cells Using Lentiviral Vectors
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    Chapter 8 Intracellular pH Measurements in Glioblastoma Cells Using the pH-Sensitive Dye BCECF
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    Chapter 9 Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro
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    Chapter 10 Metabolomic Analysis of Glioma Cells Using Nanoflow Liquid Chromatography–Tandem Mass Spectrometry
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    Chapter 11 Sample Preparation for Relative Quantitation of Proteins Using Tandem Mass Tags (TMT) and Mass Spectrometry (MS)
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    Chapter 12 Single-Cell RNA Sequencing of Glioblastoma Cells
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    Chapter 13 Evaluation of Radioresponse and Radiosensitizers in Glioblastoma Organotypic Cultures
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    Chapter 14 Orthotopic Patient-Derived Glioblastoma Xenografts in Mice
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    Chapter 15 Bioluminescent In Vivo Imaging of Orthotopic Glioblastoma Xenografts in Mice
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    Chapter 16 Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy
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    Chapter 17 Probing Glioblastoma Tissue Heterogeneity with Laser Capture Microdissection
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    Chapter 18 Flow Cytometric Identification of Tumor-Infiltrating Lymphocytes from Glioblastoma
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    Chapter 19 Modeling Glioma with Human Embryonic Stem Cell-Derived Neural Lineages
Attention for Chapter 13: Evaluation of Radioresponse and Radiosensitizers in Glioblastoma Organotypic Cultures
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Chapter title
Evaluation of Radioresponse and Radiosensitizers in Glioblastoma Organotypic Cultures
Chapter number 13
Book title
Glioblastoma
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7659-1_13
Pubmed ID
29392699
Book ISBNs
978-1-4939-7658-4, 978-1-4939-7659-1
Authors

N. Sumru Bayin, Lin Ma, Dimitris G. Placantonakis, Mary Helen Barcellos-Hoff

Abstract

Glioblastoma (GBM), a deadly primary brain malignancy, manifests pronounced radioresistance. Identifying agents that improve the sensitivity of tumor tissue to radiotherapy is critical for improving patient outcomes. The response to ionizing radiation is regulated by both cell-intrinsic and -extrinsic mechanisms. In particular, the tumor microenvironment is known to promote radioresistance in GBM. Therefore, model systems used to test radiosensitizing agents need to take into account the tumor microenvironment. We recently showed that GBM explant cultures represent an adaptable ex vivo platform for rapid and personalized testing of radiosensitizers. These explants preserve the cellular composition and tissue architecture of parental patient tumors and therefore capture the microenvironmental context that critically determines the response to radiotherapy. This chapter focuses on the detailed protocol for testing candidate radiosensitizing agents in GBM explants.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 25%
Student > Ph. D. Student 2 17%
Student > Bachelor 2 17%
Unspecified 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 7 58%
Biochemistry, Genetics and Molecular Biology 2 17%
Unspecified 1 8%
Unknown 2 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2018.
All research outputs
#20,462,806
of 23,020,670 outputs
Outputs from Methods in molecular biology
#9,945
of 13,166 outputs
Outputs of similar age
#378,193
of 442,354 outputs
Outputs of similar age from Methods in molecular biology
#1,193
of 1,498 outputs
Altmetric has tracked 23,020,670 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,166 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,354 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,498 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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