Title |
Dissecting asthma using focused transgenic modeling and functional genomics
|
---|---|
Published in |
The Journal of Allergy and Clinical Immunology, August 2005
|
DOI | 10.1016/j.jaci.2005.03.024 |
Pubmed ID | |
Authors |
Douglas A. Kuperman, Christina C. Lewis, Prescott G. Woodruff, Madeleine W. Rodriguez, Yee Hwa Yang, Gregory M. Dolganov, John V. Fahy, David J. Erle |
Abstract |
Asthma functional genomics studies are challenging because it is difficult to relate gene expression changes to specific disease mechanisms or pathophysiologic features. Use of simplified model systems might help to address this problem. One such model is the IL-13/Epi (IL-13-overexpressing transgenic mice with STAT6 expression limited to epithelial cells) focused transgenic mouse, which isolates the effects of a single mediator, IL-13, on a single cell type, the airway epithelial cell. These mice develop airway hyperreactivity and mucus overproduction but not airway inflammation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 59 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 25% |
Researcher | 12 | 20% |
Professor > Associate Professor | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Student > Bachelor | 3 | 5% |
Other | 9 | 15% |
Unknown | 13 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 33% |
Biochemistry, Genetics and Molecular Biology | 9 | 15% |
Medicine and Dentistry | 8 | 13% |
Immunology and Microbiology | 5 | 8% |
Mathematics | 1 | 2% |
Other | 2 | 3% |
Unknown | 16 | 26% |