Title |
Clinical Indications for Carbon Ion Radiotherapy
|
---|---|
Published in |
Clinical Oncology, May 2018
|
DOI | 10.1016/j.clon.2018.01.006 |
Pubmed ID | |
Authors |
O. Mohamad, S. Yamada, M. Durante |
Abstract |
Compared with photon and proton therapy, carbon ion radiotherapy (CIRT) offers potentially superior dose distributions, which may permit dose escalation with the potential for improved sparing of adjacent normal tissues. CIRT has increased biological effectiveness leading to increased tumour killing compared with other radiation modalities. Here we review these biophysical properties and provide a comprehensive evaluation of the current clinical evidence available for different tumour types treated with CIRT. We suggest that patient selection for CIRT should move away from the traditional viewpoint, which confines use to deep-seated hypoxic tumours that are adjacent to radiosensitive structures. A more integrated translational approach is required for the future as densely ionising C-ions elicit a distinct signal response pathway compared with sparsely ionising X-rays. This makes CIRT a biologically distinct treatment compared with conventional radiotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 30% |
United States | 1 | 10% |
Switzerland | 1 | 10% |
Netherlands | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 5 | 50% |
Members of the public | 4 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 22% |
Other | 6 | 9% |
Student > Ph. D. Student | 6 | 9% |
Student > Bachelor | 6 | 9% |
Professor | 3 | 4% |
Other | 9 | 13% |
Unknown | 22 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 19% |
Physics and Astronomy | 11 | 16% |
Nursing and Health Professions | 4 | 6% |
Engineering | 4 | 6% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 4 | 6% |
Unknown | 29 | 43% |