↓ Skip to main content

The Pivotal Role of Insulin-Like Growth Factor I in Normal Mammary Development

Overview of attention for article published in Endocrinology and metabolism clinics of North America (Print), September 2011
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)

Mentioned by

blogs
1 blog
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
26 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The Pivotal Role of Insulin-Like Growth Factor I in Normal Mammary Development
Published in
Endocrinology and metabolism clinics of North America (Print), September 2011
DOI 10.1016/j.ecl.2011.06.001
Pubmed ID
Authors

David L. Kleinberg, Mary Helen Barcellos-Hoff

Abstract

Mammary development begins in puberty in response to an estrogen (E(2)) surge. E(2) does not act alone. It relies on pituitary growth hormone (GH) to induce insulin-like growth factor I (IGF-I) production in the mammary stromal compartment. In turn, IGF-I permits E(2) (and progesterone) action. During puberty, E(2) and IGF-I synergize for ductal morphogenesis. During pregnancy, progesterone joins IGF-I and E(2) to stimulate secretory differentiation necessary to produce milk. Prolactin stimulates milk production, while transforming growth factor-β inhibits proliferation. The orchestrated action of hormones, growth factors, and receptors necessary for mammary development and function are also critical in breast cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 23%
Student > Master 5 19%
Other 3 12%
Professor > Associate Professor 3 12%
Student > Doctoral Student 2 8%
Other 6 23%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 12 46%
Agricultural and Biological Sciences 5 19%
Biochemistry, Genetics and Molecular Biology 2 8%
Nursing and Health Professions 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 2 8%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2018.
All research outputs
#2,863,582
of 25,373,627 outputs
Outputs from Endocrinology and metabolism clinics of North America (Print)
#88
of 734 outputs
Outputs of similar age
#14,318
of 136,082 outputs
Outputs of similar age from Endocrinology and metabolism clinics of North America (Print)
#1
of 3 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 734 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,082 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them