You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function
|
|---|---|
| Published in |
Nature Communications, August 2018
|
| DOI | 10.1038/s41467-018-05816-y |
| Pubmed ID | |
| Authors |
A. Laustsen, R. O. Bak, C. Krapp, L. Kjær, J. H. Egedahl, C. C. Petersen, S. Pillai, H. Q. Tang, N. Uldbjerg, M. Porteus, N. R. Roan, M. Nyegaard, P. W. Denton, M. R. Jakobsen |
| Abstract |
Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34+ hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited induction of type I interferon (IFN) and IL-6 upon TLR7 and TLR9 agonists treatment; by contrast, cGAS or RIG-I agonists-mediated activation is not altered. Importantly, after priming with type I and II IFN, these precursor pDCs attain a phenotype and functional activity similar to that of peripheral blood-derived pDCs. Data from CRISPR/Cas9-mediated genome editing of HSPCs further show that HSPC-pDCs with genetic modifications can be obtained, and that expression of the IFN-α receptor is essential for the optimal function, but dispensable for the differentiation, of HSPC-pDC percursor. Our results thus demonstrate the biological effects of IFNs for regulating pDC function, and provide the means of generating of gene-modified human pDCs. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 11% |
| United Kingdom | 1 | 11% |
| Denmark | 1 | 11% |
| Portugal | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Science communicators (journalists, bloggers, editors) | 3 | 33% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Researcher | 10 | 16% |
| Other | 6 | 10% |
| Student > Master | 5 | 8% |
| Student > Bachelor | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 18 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 14 | 23% |
| Biochemistry, Genetics and Molecular Biology | 9 | 15% |
| Medicine and Dentistry | 6 | 10% |
| Agricultural and Biological Sciences | 3 | 5% |
| Engineering | 3 | 5% |
| Other | 9 | 15% |
| Unknown | 18 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2023.
All research outputs
#3,573,853
of 25,191,684 outputs
Outputs from Nature Communications
#33,911
of 55,675 outputs
Outputs of similar age
#67,583
of 340,391 outputs
Outputs of similar age from Nature Communications
#900
of 1,444 outputs
Altmetric has tracked 25,191,684 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 55,675 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,391 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 1,444 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.