You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, July 2010
|
| DOI | 10.1073/pnas.1009426107 |
| Pubmed ID | |
| Authors |
Sukhvinder S. Sidhu, Shaopeng Yuan, Anh L. Innes, Sheena Kerr, Prescott G. Woodruff, Lydia Hou, Susan J. Muller, John V. Fahy |
| Abstract |
Periostin is considered to be a matricellular protein with expression typically confined to cells of mesenchymal origin. Here, by using in situ hybridization, we show that periostin is specifically up-regulated in bronchial epithelial cells of asthmatic subjects, and in vitro, we show that periostin protein is basally secreted by airway epithelial cells in response to IL-13 to influence epithelial cell function, epithelial-mesenchymal interactions, and extracellular matrix organization. In primary human bronchial epithelial cells stimulated with periostin and epithelial cells overexpressing periostin, we reveal a function for periostin in stimulating the TGF-beta signaling pathway in a mechanism involving matrix metalloproteinases 2 and 9. Furthermore, conditioned medium from the epithelial cells overexpressing periostin caused TGF-beta-dependent secretion of type 1 collagen by airway fibroblasts. In addition, mixing recombinant periostin with type 1 collagen in solution caused a dramatic increase in the elastic modulus of the collagen gel, indicating that periostin alters collagen fibrillogenesis or cross-linking and leads to stiffening of the matrix. Epithelial cell-derived periostin in asthma has roles in TGF-beta activation and collagen gel elasticity in asthma. |
Mendeley readers
The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Korea, Republic of | 1 | <1% |
| Germany | 1 | <1% |
| Egypt | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 191 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 21% |
| Researcher | 36 | 18% |
| Other | 15 | 8% |
| Student > Master | 15 | 8% |
| Student > Postgraduate | 14 | 7% |
| Other | 41 | 21% |
| Unknown | 35 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 61 | 31% |
| Agricultural and Biological Sciences | 42 | 21% |
| Biochemistry, Genetics and Molecular Biology | 25 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
| Engineering | 6 | 3% |
| Other | 15 | 8% |
| Unknown | 42 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 January 2022.
All research outputs
#7,080,750
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#59,831
of 101,438 outputs
Outputs of similar age
#31,434
of 98,512 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#394
of 666 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,512 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 666 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.