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Biphasic versus monophasic shock waveform for conversion of atrial fibrillation The results of an international randomized, double-blind multicenter trial

Overview of attention for article published in JACC, June 2002
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Title
Biphasic versus monophasic shock waveform for conversion of atrial fibrillation The results of an international randomized, double-blind multicenter trial
Published in
JACC, June 2002
DOI 10.1016/s0735-1097(02)01898-3
Pubmed ID
Authors

Richard L Page, Richard E Kerber, James K Russell, Tom Trouton, Johan Waktare, Donna Gallik, Jeff E Olgin, Philippe Ricard, Gavin W Dalzell, Ramakota Reddy, Ralph Lazzara, Kerry Lee, Mark Carlson, Blair Halperin, Gust H Bardy, BiCard Investigators

Abstract

This study compared a biphasic waveform with a conventional monophasic waveform for cardioversion of atrial fibrillation (AF). Biphasic shock waveforms have been demonstrated to be superior to monophasic shocks for termination of ventricular fibrillation, but data regarding biphasic shocks for conversion of AF are still emerging. In an international, multicenter, randomized, double-blind clinical trial, we compared the effectiveness of damped sine wave monophasic versus impedance-compensated truncated exponential biphasic shocks for the cardioversion of AF. Patients received up to five shocks, as necessary for conversion: 100 J, 150 J, 200 J, a fourth shock at maximum output for the initial waveform (200 J biphasic, 360 J monophasic) and a final cross-over shock at maximum output of the alternate waveform. Analysis included 107 monophasic and 96 biphasic patients. The success rate was higher for biphasic than for monophasic shocks at each of the three shared energy levels (100 J: 60% vs. 22%, p < 0.0001; 150 J: 77% vs. 44%, p < 0.0001; 200 J: 90% vs. 53%, p < 0.0001). Through four shocks, at a maximum of 200 J, biphasic performance was similar to monophasic performance at 360 J (91% vs. 85%, p = 0.29). Biphasic patients required fewer shocks (1.7 +/- 1.0 vs. 2.8 +/- 1.2, p < 0.0001) and lower total energy delivered (217 +/- 176 J vs. 548 +/- 331 J, p < 0.0001). The biphasic shock waveform was also associated with a lower frequency of dermal injury (17% vs. 41%, p < 0.0001). For the cardioversion of AF, a biphasic shock waveform has greater efficacy, requires fewer shocks and lower delivered energy, and results in less dermal injury than a monophasic shock waveform.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Germany 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 26%
Student > Doctoral Student 7 15%
Other 6 13%
Student > Bachelor 6 13%
Student > Postgraduate 4 9%
Other 9 19%
Unknown 3 6%
Readers by discipline Count As %
Medicine and Dentistry 30 64%
Engineering 6 13%
Agricultural and Biological Sciences 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Veterinary Science and Veterinary Medicine 1 2%
Other 2 4%
Unknown 3 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2017.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from JACC
#9,860
of 16,741 outputs
Outputs of similar age
#42,702
of 126,580 outputs
Outputs of similar age from JACC
#34
of 82 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
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