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Estimated Daily Phthalate Exposures in a Population of Mothers of Male Infants Exhibiting Reduced Anogenital Distance

Overview of attention for article published in EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, February 2006
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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2 news outlets
policy
1 policy source
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1 Facebook page

Citations

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180 Dimensions

Readers on

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117 Mendeley
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Title
Estimated Daily Phthalate Exposures in a Population of Mothers of Male Infants Exhibiting Reduced Anogenital Distance
Published in
EHP toxicogenomics journal of the National Institute of Environmental Health Sciences, February 2006
DOI 10.1289/ehp.8663
Pubmed ID
Authors

Kevin Marsee, Tracey J. Woodruff, Daniel A. Axelrad, Antonia M. Calafat, Shanna H. Swan

Abstract

Phthalate diesters have been shown to be developmental and reproductive toxicants in animal studies. A recent epidemiologic study showed certain phthalates to be significantly associated with reduced anogenital distance in human male infants, the first evidence of subtle developmental effects in human male infants exposed prenatally to phthalates. We used two previously published methods to estimate the daily phthalate exposures for the four phthalates whose urinary metabolites were statistically significantly associated with developmental effects in the 214 mother-infant pairs [di-n-butyl phthalate (DnBP) , diethyl phthalate (DEP) , butylbenzyl phthalate (BBzP) , diisobutyl phthalate (DiBP) ] and for another important phthalate [di-2-ethylhexyl phthalate (DEHP) ]. We estimated the median and 95th percentile of daily exposures to DBP to be 0.99 and 2.68 microg/kg/day, respectively ; for DEP, 6.64 and 112.3 microg/kg/day ; for BBzP, 0.50 and 2.47 microg/kg/day ; and for DEHP, 1.32 and 9.32 microg/kg/day. The U.S. Environmental Protection Agency (EPA) reference doses for these chemicals are 100 (DBP) , 800 (DEP) , 200 (BBzP) , and 20 (DEHP) microg/kg/day. The median and 95th percentile exposure estimates for the phthalates associated with reduced anogenital distance in the study population are substantially lower than current U.S. EPA reference doses for these chemicals and could be informative to any updates of the hazard assessments and risk assessments for these chemicals.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Spain 1 <1%
United Kingdom 1 <1%
Unknown 113 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 18%
Student > Master 20 17%
Researcher 16 14%
Student > Bachelor 14 12%
Other 9 8%
Other 21 18%
Unknown 16 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 15%
Environmental Science 17 15%
Medicine and Dentistry 15 13%
Chemistry 11 9%
Biochemistry, Genetics and Molecular Biology 7 6%
Other 29 25%
Unknown 20 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2017.
All research outputs
#1,793,318
of 25,374,917 outputs
Outputs from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#1,441
of 8,404 outputs
Outputs of similar age
#4,826
of 170,240 outputs
Outputs of similar age from EHP toxicogenomics journal of the National Institute of Environmental Health Sciences
#20
of 90 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,404 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,240 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.