Title |
Long-term Comparative Immunogenicity of Protein Conjugate and Free Polysaccharide Pneumococcal Vaccines in Chronic Obstructive Pulmonary Disease
|
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Published in |
Clinical Infectious Diseases, May 2012
|
DOI | 10.1093/cid/cis513 |
Pubmed ID | |
Authors |
Mark T. Dransfield, Sarah Harnden, Robert L. Burton, Richard K. Albert, William C. Bailey, Richard Casaburi, John Connett, J. Allen D. Cooper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Barry Make, Nathaniel Marchetti, Fernando J. Martinez, Charlene McEvoy, Moon H. Nahm, Dennis E. Niewoehner, Janos Porszasz, John Reilly, Paul D. Scanlon, Steven M. Scharf, Frank C. Sciurba, George R. Washko, Prescott G. Woodruff, Stephen C. Lazarus |
Abstract |
Although the 23-valent pneumococcal polysaccharide vaccine (PPSV23) protects against invasive disease in young healthy persons, randomized controlled trials in chronic obstructive pulmonary disease (COPD) have demonstrated no benefit in the intention-to-treat population. We previously reported that the 7-valent diphtheria-conjugated pneumococcal polysaccharide vaccine (PCV7) is safe and induced greater serotype-specific immunoglobulin G (IgG) and functional antibody than did PPSV23 1 month after vaccination. We hypothesized that these advantages would persist at 1 and 2 years. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Spain | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Kenya | 1 | 1% |
Unknown | 66 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 13% |
Researcher | 9 | 13% |
Other | 6 | 9% |
Student > Bachelor | 6 | 9% |
Student > Master | 5 | 7% |
Other | 16 | 24% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 43% |
Agricultural and Biological Sciences | 4 | 6% |
Computer Science | 3 | 4% |
Immunology and Microbiology | 2 | 3% |
Mathematics | 1 | 1% |
Other | 6 | 9% |
Unknown | 23 | 34% |