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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer
|
|---|---|
| Published in |
Oncogene, June 2016
|
| DOI | 10.1038/onc.2016.185 |
| Pubmed ID | |
| Authors |
L A Selth, R Das, S L Townley, I Coutinho, A R Hanson, M M Centenera, N Stylianou, K Sweeney, C Soekmadji, L Jovanovic, C C Nelson, A Zoubeidi, L M Butler, G J Goodall, B G Hollier, P A Gregory, W D Tilley |
| Abstract |
MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely correlated with epithelial-mesenchymal transition signatures (EMT) in clinical samples and can drive mesenchymal-epithelial transition (MET) in model systems. Indeed, miR-375 potently inhibited invasion and migration of multiple prostate cancer lines. The transcription factor YAP1 was found to be a direct target of miR-375 in prostate cancer. Knockdown of YAP1 phenocopied miR-375 overexpression, and overexpression of YAP1 rescued anti-invasive effects mediated by miR-375. Furthermore, transcription of the miR-375 gene was shown to be directly repressed by the EMT transcription factor, ZEB1. Analysis of multiple patient cohorts provided evidence for this ZEB1-miR-375-YAP1 regulatory circuit in clinical samples. Despite its anti-invasive and anti-EMT capacities, plasma miR-375 was found to be correlated with circulating tumor cells in men with metastatic disease. Collectively, this study provides new insight into the function of miR-375 in prostate cancer, and more broadly identifies a novel pathway controlling epithelial plasticity and tumor cell invasion in this disease.Oncogene advance online publication, 6 June 2016; doi:10.1038/onc.2016.185. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Members of the public | 1 | 33% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 22% |
| Researcher | 13 | 16% |
| Student > Master | 8 | 10% |
| Student > Bachelor | 7 | 9% |
| Professor > Associate Professor | 5 | 6% |
| Other | 17 | 22% |
| Unknown | 12 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 37% |
| Medicine and Dentistry | 15 | 19% |
| Agricultural and Biological Sciences | 11 | 14% |
| Chemistry | 2 | 3% |
| Social Sciences | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 16 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2016.
All research outputs
#2,713,029
of 22,876,619 outputs
Outputs from Oncogene
#888
of 10,655 outputs
Outputs of similar age
#49,636
of 340,764 outputs
Outputs of similar age from Oncogene
#32
of 124 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,655 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,764 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.