Title |
Placebo Adherence and Mortality in the Heart and Estrogen/Progestin Replacement Study
|
---|---|
Published in |
American Journal of Medicine, August 2012
|
DOI | 10.1016/j.amjmed.2012.02.014 |
Pubmed ID | |
Authors |
Amy M. Padula, Alice R. Pressman, Eric Vittinghoff, Deborah Grady, John Neuhaus, Lynn Ackerson, Peter Rudd, Andrew L. Avins |
Abstract |
Analyses from double-blind randomized trials have reported lower mortality among participants who were more adherent to placebo compared with those who were less adherent. We explored this phenomenon by analyzing data from the placebo arm of the Heart and Estrogen/Progestin Replacement Study (HERS), a randomized, double-blind, placebo-controlled trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Our primary aim was to measure and explain the association between adherence to placebo and total mortality among the placebo-allocated participants in the HERS. Secondary aims included assessment of the association between placebo adherence and cause-specific morbidity and mortality. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 22% |
Student > Ph. D. Student | 7 | 17% |
Student > Master | 5 | 12% |
Other | 4 | 10% |
Researcher | 2 | 5% |
Other | 5 | 12% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 39% |
Psychology | 4 | 10% |
Nursing and Health Professions | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Other | 5 | 12% |
Unknown | 8 | 20% |