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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals
|
|---|---|
| Published in |
JAMA Cardiology, July 2016
|
| DOI | 10.1001/jamacardio.2016.1185 |
| Pubmed ID | |
| Authors |
Jason D. Roberts, Donglei Hu, Susan R. Heckbert, Alvaro Alonso, Thomas A. Dewland, Eric Vittinghoff, Yongmei Liu, Bruce M. Psaty, Jeffrey E. Olgin, Jared W. Magnani, Scott Huntsman, Esteban G. Burchard, Dan E. Arking, Kirsten Bibbins-Domingo, Tamara B. Harris, Marco V. Perez, Elad Ziv, Gregory M. Marcus |
| Abstract |
White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors. To determine whether 9 single-nucleotide polymorphisms (SNPs) associated with AF account for this paradoxical differential racial risk for AF and to use admixture mapping to search genome-wide for loci that may account for this phenomenon. Genome-wide admixture analysis and candidate SNP study involving 3 population-based cohort studies that were initiated between 1987 and 1997, including the Cardiovascular Health Study (CHS) (n = 4173), the Atherosclerosis Risk in Communities (ARIC) (n = 12 341) study, and the Health, Aging, and Body Composition (Health ABC) (n = 1015) study. In all 3 studies, race was self-identified. Cox proportional hazards regression models and the proportion of treatment effect method were used to determine the impact of 9 AF-risk SNPs among participants from CHS and the ARIC study. The present study began July 1, 2012, and was completed in 2015. Incident AF systematically ascertained using clinic visit electrocardiograms, hospital discharge diagnosis codes, death certificates, and Medicare claims data. A single SNP, rs10824026 (chromosome 10: position 73661450), was found to significantly mediate the higher risk for AF in white participants compared with black participants in CHS (11.4%; 95% CI, 2.9%-29.9%) and ARIC (31.7%; 95% CI, 16.0%-53.0%). Admixture mapping was performed in a meta-analysis of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015). No loci that reached the prespecified statistical threshold for genome-wide significance were identified. The rs10824026 SNP on chromosome 10q22 mediates a modest proportion of the increased risk of AF among white individuals compared with black individuals, potentially through an effect on gene expression levels of MYOZ1. No additional genetic variants accounting for a significant portion of the differential racial risk of AF were identified with genome-wide admixture mapping, suggesting that additional genetic or environmental influences beyond single SNPs in isolation may account for the paradoxical racial risk of AF among white individuals and black individuals. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 44% |
| Australia | 1 | 6% |
| Israel | 1 | 6% |
| Mexico | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 6 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 67% |
| Practitioners (doctors, other healthcare professionals) | 4 | 22% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 15% |
| Student > Ph. D. Student | 5 | 9% |
| Professor | 5 | 9% |
| Student > Bachelor | 4 | 8% |
| Other | 4 | 8% |
| Other | 14 | 26% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 30% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Agricultural and Biological Sciences | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 19 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2019.
All research outputs
#844,307
of 25,374,647 outputs
Outputs from JAMA Cardiology
#805
of 2,143 outputs
Outputs of similar age
#16,205
of 367,269 outputs
Outputs of similar age from JAMA Cardiology
#32
of 75 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,143 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 94.8. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,269 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.