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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, September 2012
|
| DOI | 10.1073/pnas.1214596109 |
| Pubmed ID | |
| Authors |
Fen Huang, Hongkang Zhang, Meng Wu, Huanghe Yang, Makoto Kudo, Christian J. Peters, Prescott G. Woodruff, Owen D. Solberg, Matthew L. Donne, Xiaozhu Huang, Dean Sheppard, John V. Fahy, Paul J. Wolters, Brigid L. M. Hogan, Walter E. Finkbeiner, Min Li, Yuh-Nung Jan, Lily Yeh Jan, Jason R. Rock |
| Abstract |
Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are hallmark features of inflammatory airway diseases, including asthma. Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM. The epithelial expression is increased in asthmatics, particularly in secretory cells. Based on this and the proposed functions of CaCC, we hypothesized that TMEM16A inhibitors would negatively regulate both epithelial mucin secretion and ASM contraction. We used a high-throughput screen to identify small-molecule blockers of TMEM16A-CaCC channels. We show that inhibition of TMEM16A-CaCC significantly impairs mucus secretion in primary human airway surface epithelial cells. Furthermore, inhibition of TMEM16A-CaCC significantly reduces mouse and human ASM contraction in response to cholinergic agonists. TMEM16A-CaCC blockers, including those identified here, may positively impact multiple causes of asthma symptoms. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 2 | 1% |
| Germany | 2 | 1% |
| Portugal | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 166 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 25% |
| Researcher | 30 | 17% |
| Student > Master | 18 | 10% |
| Student > Bachelor | 14 | 8% |
| Student > Doctoral Student | 9 | 5% |
| Other | 30 | 17% |
| Unknown | 28 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 30% |
| Biochemistry, Genetics and Molecular Biology | 33 | 19% |
| Medicine and Dentistry | 16 | 9% |
| Neuroscience | 12 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Other | 17 | 10% |
| Unknown | 34 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2022.
All research outputs
#3,273,093
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#34,483
of 101,438 outputs
Outputs of similar age
#21,997
of 176,625 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#393
of 939 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,625 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 939 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.