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The Dynamic Architectural and Epigenetic Nuclear Landscape: Developing the Genomic Almanac of Biology and Disease

Overview of attention for article published in Journal of Cellular Physiology, February 2014
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Title
The Dynamic Architectural and Epigenetic Nuclear Landscape: Developing the Genomic Almanac of Biology and Disease
Published in
Journal of Cellular Physiology, February 2014
DOI 10.1002/jcp.24508
Pubmed ID
Authors

Phillip W.L. Tai, Sayyed K. Zaidi, Hai Wu, Rodrigo A. Grandy, Martin Montecino, André J. van Wijnen, Jane B. Lian, Gary S. Stein, Janet L. Stein

Abstract

Compaction of the eukaryotic genome into the confined space of the cell nucleus must occur faithfully throughout each cell cycle to retain gene expression fidelity. For decades, experimental limitations to study the structural organization of the interphase nucleus restricted our understanding of its contributions towards gene regulation and disease. However, within the past few years, our capability to visualize chromosomes in vivo with sophisticated fluorescence microscopy, and to characterize chromosomal regulatory environments via massively parallel sequencing methodologies have drastically changed how we currently understand epigenetic gene control within the context of three-dimensional nuclear structure. The rapid rate at which information on nuclear structure is unfolding brings challenges to compare and contrast recent observations with historic findings. In this review, we discuss experimental breakthroughs that have influenced how we understand and explore the dynamic structure and function of the nucleus, and how we can incorporate historical perspectives with insights acquired from the ever-evolving advances in molecular biology and pathology.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 28%
Student > Ph. D. Student 7 16%
Student > Bachelor 6 14%
Student > Master 6 14%
Other 2 5%
Other 5 12%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 40%
Biochemistry, Genetics and Molecular Biology 8 19%
Computer Science 4 9%
Neuroscience 2 5%
Medicine and Dentistry 2 5%
Other 4 9%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 November 2013.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Journal of Cellular Physiology
#4,602
of 6,257 outputs
Outputs of similar age
#177,280
of 239,321 outputs
Outputs of similar age from Journal of Cellular Physiology
#10
of 31 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,257 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,321 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.