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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
|
|---|---|
| Published in |
Cell, July 2014
|
| DOI | 10.1016/j.cell.2014.04.050 |
| Pubmed ID | |
| Authors |
Paul Andrew Muller, Balázs Koscsó, Gaurav Manohar Rajani, Korey Stevanovic, Marie-Luise Berres, Daigo Hashimoto, Arthur Mortha, Marylene Leboeuf, Xiu-Min Li, Daniel Mucida, E. Richard Stanley, Stephanie Dahan, Kara Gross Margolis, Michael David Gershon, Miriam Merad, Milena Bogunovic |
| Abstract |
Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonstrate that, in the steady state, muscularis macrophages regulate peristaltic activity of the colon. They change the pattern of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons. Enteric neurons, in turn, secrete colony stimulatory factor 1 (CSF1), a growth factor required for macrophage development. Finally, stimuli from microbial commensals regulate BMP2 expression by macrophages and CSF1 expression by enteric neurons. Our findings identify a plastic, microbiota-driven crosstalk between muscularis macrophages and enteric neurons that controls gastrointestinal motility. PAPERFLICK: |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 38% |
| France | 1 | 5% |
| Italy | 1 | 5% |
| Finland | 1 | 5% |
| Unknown | 10 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 67% |
| Practitioners (doctors, other healthcare professionals) | 4 | 19% |
| Scientists | 2 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 623 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 1% |
| United Kingdom | 2 | <1% |
| India | 1 | <1% |
| Japan | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 609 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 147 | 24% |
| Researcher | 109 | 17% |
| Student > Master | 63 | 10% |
| Student > Bachelor | 55 | 9% |
| Student > Doctoral Student | 38 | 6% |
| Other | 101 | 16% |
| Unknown | 110 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 146 | 23% |
| Immunology and Microbiology | 123 | 20% |
| Biochemistry, Genetics and Molecular Biology | 72 | 12% |
| Medicine and Dentistry | 72 | 12% |
| Neuroscience | 41 | 7% |
| Other | 41 | 7% |
| Unknown | 128 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2022.
All research outputs
#1,107,811
of 26,017,215 outputs
Outputs from Cell
#4,059
of 17,318 outputs
Outputs of similar age
#10,567
of 245,263 outputs
Outputs of similar age from Cell
#61
of 157 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,318 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,263 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.