Title |
Vancomycin-bearing Synthetic Bone Graft Delivers rhBMP-2 and Promotes Healing of Critical Rat Femoral Segmental Defects
|
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Published in |
Clinical Orthopaedics & Related Research, August 2014
|
DOI | 10.1007/s11999-014-3841-1 |
Pubmed ID | |
Authors |
Jordan D. Skelly, Jeffrey Lange, Tera M. Filion, Xinning Li, David C. Ayers, Jie Song |
Abstract |
Bone grafts simultaneously delivering therapeutic proteins and antibiotics may be valuable in orthopaedic trauma care. Previously, we developed a poly(2-hydroxyethyl methacrylate)-nanocrystalline hydroxyapatite (pHEMA-nHA) synthetic bone graft that, when preabsorbed with 400-ng rhBMP-2/7, facilitated the functional repair of critical-size rat femoral defects. Recently, we showed that pHEMA-nHA effectively retains/releases vancomycin and rhBMP-2 in vitro. The success of such a strategy requires that the incorporation of vancomycin does not compromise the structural integrity of the graft nor its ability to promote bone healing. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 18% |
Student > Master | 8 | 16% |
Researcher | 7 | 14% |
Student > Doctoral Student | 3 | 6% |
Professor | 3 | 6% |
Other | 10 | 20% |
Unknown | 10 | 20% |
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Unknown | 14 | 28% |