Title |
Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract
|
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Published in |
Trends in Immunology, June 2016
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DOI | 10.1016/j.it.2016.05.003 |
Pubmed ID | |
Authors |
Kara Gross Margolis, Michael David Gershon, Milena Bogunovic |
Abstract |
The gastrointestinal (GI) tract is the largest immune organ; in vertebrates, it is the only organ whose function is controlled by its own intrinsic enteric nervous system (ENS), but it is additionally regulated by extrinsic (sympathetic and parasympathetic) neural innervation. The GI nervous and immune systems are highly integrated in their common goal, which is to unite digestive functions with protection from ingested environmental threats. This review discusses the physiological relevance of enteric neuroimmune integration by summarizing the current knowledge of evolutionary and developmental pathways, cellular organization, and molecular mechanisms of neuroimmune interactions in health and disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 33% |
United Kingdom | 2 | 17% |
Mexico | 1 | 8% |
Belgium | 1 | 8% |
El Salvador | 1 | 8% |
Unknown | 3 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Scientists | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | <1% |
Austria | 1 | <1% |
Sweden | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 153 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 21% |
Researcher | 28 | 18% |
Student > Master | 13 | 8% |
Student > Bachelor | 11 | 7% |
Student > Doctoral Student | 10 | 6% |
Other | 29 | 18% |
Unknown | 34 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 23 | 15% |
Agricultural and Biological Sciences | 19 | 12% |
Neuroscience | 18 | 11% |
Biochemistry, Genetics and Molecular Biology | 18 | 11% |
Medicine and Dentistry | 17 | 11% |
Other | 19 | 12% |
Unknown | 44 | 28% |