| Title |
Nitric Oxide: The Forgotten Child of Tumor Metabolism
|
|---|---|
| Published in |
Trends in Cancer, August 2017
|
| DOI | 10.1016/j.trecan.2017.07.005 |
| Pubmed ID | |
| Authors |
Bahar Salimian Rizi, Abhinav Achreja, Deepak Nagrath |
| Abstract |
Nitric oxide (NO) is a signaling molecule with pleiotropic physiological roles in normal cells and pathophysiological roles in cancer. NO synthetase expression and NO synthesis are linked to altered metabolism, neoplasticity, invasiveness, chemoresistance, immune evasion, and ultimately to poor prognosis of cancer patients. Exogenous NO in the microenvironment facilitates paracrine signaling, mediates immune responses, and triggers angiogenesis. NO regulates posttranslational protein modifications, S-nitrosation, and genome-wide epigenetic modifications that can have both tumor-promoting and tumor-suppressing effects. We review mechanisms that link NO to cancer hallmarks, with a perspective of co-targeting NO metabolism with first-line therapies for improved outcome. We highlight the need for quantitative flux analysis to study NO in tumors. |
X Demographics
The data shown below were collected from the profiles of 37 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 32% |
| Germany | 2 | 5% |
| India | 1 | 3% |
| Finland | 1 | 3% |
| France | 1 | 3% |
| Japan | 1 | 3% |
| Saint Martin (French part) | 1 | 3% |
| Korea, Democratic People's Republic of | 1 | 3% |
| Korea, Republic of | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 15 | 41% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 46% |
| Scientists | 17 | 46% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
| Unknown | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 125 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 19% |
| Researcher | 23 | 18% |
| Student > Master | 14 | 11% |
| Student > Postgraduate | 7 | 6% |
| Student > Bachelor | 6 | 5% |
| Other | 20 | 16% |
| Unknown | 31 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 22% |
| Medicine and Dentistry | 12 | 10% |
| Chemistry | 12 | 10% |
| Agricultural and Biological Sciences | 12 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 13 | 10% |
| Unknown | 41 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2022.
All research outputs
#1,751,023
of 25,738,558 outputs
Outputs from Trends in Cancer
#231
of 850 outputs
Outputs of similar age
#33,353
of 327,960 outputs
Outputs of similar age from Trends in Cancer
#10
of 20 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 850 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,960 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.