Title |
Circadian autophagy rhythm: a link between clock and metabolism?
|
---|---|
Published in |
Trends in Endocrinology & Metabolism, April 2012
|
DOI | 10.1016/j.tem.2012.03.004 |
Pubmed ID | |
Authors |
Di Ma, Siming Li, Matthew M. Molusky, Jiandie D. Lin |
Abstract |
Nutrient and energy metabolism in mammals exhibits a strong diurnal rhythm that aligns with the body clock. Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks. Recent work has demonstrated that autophagy is rhythmically activated in a clock-dependent manner. Because autophagy is a conserved biological process that contributes to nutrient and cellular homeostasis, its cyclic induction may provide a novel link between clock and metabolism. This review discusses the mechanisms underlying circadian autophagy regulation, the role of rhythmic autophagy in nutrient and energy metabolism, and its implications in physiology and metabolic disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 16% |
United Kingdom | 2 | 4% |
India | 2 | 4% |
Indonesia | 1 | 2% |
Brazil | 1 | 2% |
France | 1 | 2% |
Canada | 1 | 2% |
Czechia | 1 | 2% |
Comoros | 1 | 2% |
Other | 1 | 2% |
Unknown | 27 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 29 | 64% |
Practitioners (doctors, other healthcare professionals) | 10 | 22% |
Scientists | 4 | 9% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | 1% |
Brazil | 1 | <1% |
Israel | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Unknown | 170 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 20% |
Researcher | 31 | 17% |
Student > Master | 22 | 12% |
Student > Bachelor | 13 | 7% |
Professor > Associate Professor | 10 | 6% |
Other | 32 | 18% |
Unknown | 35 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 53 | 30% |
Biochemistry, Genetics and Molecular Biology | 33 | 19% |
Medicine and Dentistry | 19 | 11% |
Neuroscience | 16 | 9% |
Nursing and Health Professions | 4 | 2% |
Other | 18 | 10% |
Unknown | 35 | 20% |