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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer
|
|---|---|
| Published in |
Clinical Cancer Research, January 2019
|
| DOI | 10.1158/1078-0432.ccr-18-1521 |
| Pubmed ID | |
| Authors |
Daniel L.J. Thorek, Anson T. Ku, Nicholas Mitsiades, Darren Veach, Philip A. Watson, Dipti Metha, Sven-Erik Strand, Sai Kiran Sharma, Jason S. Lewis, Diane S. Abou, Hans G. Lilja, Steven M. Larson, Michael R. McDevitt, David Ulmert |
| Abstract |
The impact of androgen receptor (AR) activity in breast cancer (BCa) biology is unclear. We characterized and tested a novel therapy to an AR-governed target in BCa. We evaluated the expression of prototypical AR-gene products human kallikrein 2 (hK2) and Prostate Specific Antigen (PSA) in BCa models. We screened 13 well-characterized BCa cell lines for hK2 and PSA production upon in-vitro hormone stimulation by testosterone (DHT). AR-positive lines were further evaluated by exposure to estrogen (17β-Estradiol) and the synthetic progestin D-Norgestrel. We then evaluated an anti-hK2 targeted radiotherapy platform (hu11B6), labeled with alpha (a)-particle emitting Actinium-225, to specifically treat AR-expressing BCa xenografts under hormone stimulation. D-Norgestrel and DHT activated the AR-pathway, while 17β-Estradiol did not. Competitive binding for AR protein showed similar affinity between DHT and D-Norgestrel; indicating direct AR-ligand interaction. In vivo production of hK2 was sufficient to achieve site-specific delivery of therapeutic radionuclide to tumor tissue at >20-fold over background muscle uptake; effecting long-term local tumor control. [225Ac]hu11B6 targeted radiotherapy was potentiated by DHT and by D-Norgestrel in murine xenograft models of BCa. AR activity in BCa correlates with kallikrein related peptidase-2 and can be activated by D-Norgestrel, a common contraceptive, and AR-induction can be harnessed for hK2-targeted BCa a-emitter radiotherapy. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 56% |
| Norway | 2 | 22% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Scientists | 1 | 11% |
| Unknown | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 11% |
| Student > Bachelor | 4 | 9% |
| Student > Ph. D. Student | 3 | 6% |
| Student > Postgraduate | 3 | 6% |
| Student > Master | 3 | 6% |
| Other | 7 | 15% |
| Unknown | 22 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 11% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Engineering | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 25 | 53% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2020.
All research outputs
#6,468,965
of 23,103,903 outputs
Outputs from Clinical Cancer Research
#6,022
of 12,668 outputs
Outputs of similar age
#146,131
of 470,354 outputs
Outputs of similar age from Clinical Cancer Research
#136
of 267 outputs
Altmetric has tracked 23,103,903 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 12,668 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 470,354 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 267 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.