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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Longitudinal Alzheimer’s Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections
|
|---|---|
| Published in |
Cell Reports, July 2018
|
| DOI | 10.1016/j.celrep.2018.06.001 |
| Pubmed ID | |
| Authors |
Taylor W. Schmitz, Marieke Mur, Meghmik Aghourian, Marc-Andre Bedard, R. Nathan Spreng, for the Alzheimer’s Disease Neuroimaging Initiative |
| Abstract |
The cholinergic neurons of the basal forebrain (BF) provide virtually all of the brain's cortical and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early Alzheimer's disease (AD) and may trigger the emergence of neuropathology in their cortico-amygdalar projection system through cholinergic denervation and trans-synaptic spreading of misfolded proteins. We examined whether longitudinal degeneration within the BF can explain longitudinal cortico-amygdalar degeneration in older human adults with abnormal cerebrospinal fluid biomarkers of AD neuropathology. We focused on two BF subregions, which are known to innervate cortico-amygdalar regions via two distinct macroscopic cholinergic projections. To further assess whether structural degeneration of these regions in AD reflects cholinergic denervation, we used the [18F] FEOBV radiotracer, which binds to cortico-amygdalar cholinergic terminals. We found that the two BF subregions explain spatially distinct patterns of cortico-amygdalar degeneration, which closely reflect their cholinergic projections, and overlap with [18F] FEOBV indices of cholinergic denervation. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 9 | 30% |
| United States | 3 | 10% |
| Netherlands | 2 | 7% |
| United Kingdom | 2 | 7% |
| Germany | 1 | 3% |
| Mexico | 1 | 3% |
| Ireland | 1 | 3% |
| Singapore | 1 | 3% |
| Australia | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 9 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 53% |
| Scientists | 12 | 40% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 121 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 23% |
| Researcher | 20 | 17% |
| Student > Master | 14 | 12% |
| Student > Doctoral Student | 8 | 7% |
| Student > Postgraduate | 6 | 5% |
| Other | 19 | 16% |
| Unknown | 26 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 37 | 31% |
| Psychology | 15 | 12% |
| Medicine and Dentistry | 11 | 9% |
| Agricultural and Biological Sciences | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Other | 14 | 12% |
| Unknown | 31 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2019.
All research outputs
#633,849
of 25,385,509 outputs
Outputs from Cell Reports
#1,377
of 12,965 outputs
Outputs of similar age
#13,754
of 341,606 outputs
Outputs of similar age from Cell Reports
#37
of 308 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,965 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 308 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.