| Title |
Serum Biomarkers of Exposure to Perfluoroalkyl Substances in Relation to Serum Testosterone and Measures of Thyroid Function among Adults and Adolescents from NHANES 2011–2012
|
|---|---|
| Published in |
International Journal of Environmental Research and Public Health, May 2015
|
| DOI | 10.3390/ijerph120606098 |
| Pubmed ID | |
| Authors |
Ryan C Lewis, Lauren E Johns, John D Meeker |
| Abstract |
Perfluoroalkyl substances (PFASs) are a group of environmentally-persistent chemicals that have been widely used in many industrial applications. There is human and animal evidence that PFASs may alter levels of reproductive and thyroid-related hormones. However, human studies on the potential age-related effects of PFASs on these outcomes among males and females are limited. We explored the relationship between serum PFASs and serum total testosterone (T), thyroid stimulating hormone (TSH), and free and total triiodothyronine (FT3, TT3) and thyroxine (FT4, TT4) among males and females 12 to 80 years of age from the 2011-2012 cycle of the National Health and Nutrition Examination Survey. Associations were assessed using multiple linear regression models that were stratified on sex and age categories. Effect estimates from the majority of the adjusted models were not statistically significant. However, exposure to PFASs may be associated with increases in FT3, TT3, and FT4 among adult females, but during adolescence, PFASs may be related to increases in TSH among males and decreases in TSH among females. No significant relationships were observed between PFASs and T in any of the models. These findings suggest that exposure to PFASs may disrupt thyroid hormone homeostasis. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 5 | 33% |
| Germany | 1 | 7% |
| Unknown | 9 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 253 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 17% |
| Student > Master | 28 | 11% |
| Researcher | 25 | 10% |
| Student > Bachelor | 18 | 7% |
| Other | 12 | 5% |
| Other | 37 | 15% |
| Unknown | 92 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 36 | 14% |
| Engineering | 16 | 6% |
| Chemistry | 14 | 6% |
| Medicine and Dentistry | 12 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Other | 55 | 22% |
| Unknown | 112 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1307. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2024.
All research outputs
#10,290
of 25,765,370 outputs
Outputs from International Journal of Environmental Research and Public Health
#14
of 32,142 outputs
Outputs of similar age
#61
of 280,244 outputs
Outputs of similar age from International Journal of Environmental Research and Public Health
#1
of 147 outputs
Altmetric has tracked 25,765,370 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
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We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.