| Title |
Functional Outcomes of Acute Inpatient Rehabilitation in Patients With Chronic Graft‐Versus‐Host Disease
|
|---|---|
| Published in |
PM&R, November 2017
|
| DOI | 10.1016/j.pmrj.2017.11.007 |
| Pubmed ID | |
| Authors |
Jason Leung, Sean Smith, Claire Kalpakjian |
| Abstract |
Growing numbers of allogeneic stem cell transplants (HSCT) and improved post-transplant care have led to an increase of individuals with chronic graft versus host disease (cGVHD). Although cGVHD leads to functional impairment for many, there is limited literature regarding the benefits of acute inpatient rehabilitation for cGVHD patients. To assess Functional Independence Measure (FIM) outcomes of cGVHD patients during acute inpatient rehabilitation, and to compare inpatient rehabilitation outcomes to burn patients, a rehabilitation patient population with similar co-morbidities. Retrospective chart review. Acute rehabilitation center at a large academic medical center. 37 adult patients with cGVHD and 30 with burn injuries admitted to inpatient rehabilitation from 2010-2015. Linear regression analysis to evaluate group (cGVHD vs. burn) differences in functional gains. Effect size and minimal detectable change (MDC90) were used to evaluate change in FIM outcomes. Total FIM gain, motor FIM gain, and FIM efficiency. cGVHD patients had statistically significant lower functional gains than burn patients, with an average of 11.66 fewer total FIM points (p < .001), 10.54 fewer motor FIM points (p = .01), and 2.45 units less of FIM efficiency (p = .01). At the time of discharge, 7 (18%) patients with cGVHD exceeded the MDC90 values for total FIM gain vs. 9 (30%) patients with burn injuries (p = .26). Eight (21%) patients with cGVHD exceeded the MDC90 for motor FIM gain vs. 13 (43%) patients with burn injuries (p = .048). Effect sizes for cGVHD and burn patients were moderate to large, respectively, with burn patients having nearly twice the magnitude of gains as cGVHD patients. Despite achieving more modest functional gains than patients with burn injuries, patients with cGVHD improved in function after acute inpatient rehabilitation. If replicated in larger studies, patients with functional impairment from cGVHD can be considered for inpatient rehabilitation. Future work should also determine minimal clinically important differences in function gain from inpatient rehabilitation for cGVHD patients. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 82% |
| Chile | 1 | 9% |
| Unknown | 1 | 9% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 45% |
| Scientists | 4 | 36% |
| Science communicators (journalists, bloggers, editors) | 1 | 9% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 10% |
| Researcher | 3 | 10% |
| Student > Doctoral Student | 2 | 6% |
| Student > Bachelor | 2 | 6% |
| Student > Ph. D. Student | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 17 | 55% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 16% |
| Nursing and Health Professions | 3 | 10% |
| Sports and Recreations | 1 | 3% |
| Computer Science | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 19 | 61% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2018.
All research outputs
#5,038,932
of 24,417,958 outputs
Outputs from PM&R
#452
of 1,717 outputs
Outputs of similar age
#84,340
of 330,823 outputs
Outputs of similar age from PM&R
#18
of 41 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,717 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.