| Title |
Association between peri‐operative angiotensin‐converting enzyme inhibitors and angiotensin‐2 receptor blockers and acute kidney injury in major elective non‐cardiac surgery: a multicentre, prospective cohort study
|
|---|---|
| Published in |
Anaesthesia, July 2018
|
| DOI | 10.1111/anae.14349 |
| Pubmed ID | |
| Authors |
STARSurg Collaborative |
| Abstract |
The peri-operative use of angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers is thought to be associated with an increased risk of postoperative acute kidney injury. To reduce this risk, these agents are commonly withheld during the peri-operative period. This study aimed to investigate if withholding angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers peri-operatively reduces the risk of acute kidney injury following major non-cardiac surgery. Patients undergoing elective major surgery on the gastrointestinal tract and/or the liver were eligible for inclusion in this prospective study. The primary outcome was the development of acute kidney injury within seven days of operation. Adjusted multi-level models were used to account for centre-level effects and propensity score matching was used to reduce the effects of selection bias between treatment groups. A total of 949 patients were included from 160 centres across the UK and Republic of Ireland. From this population, 573 (60.4%) patients had their angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers withheld during the peri-operative period. One hundred and seventy-five (18.4%) patients developed acute kidney injury; there was no difference in the incidence of acute kidney injury between patients who had their angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers continued or withheld (107 (18.7%) vs. 68 (18.1%), respectively; p = 0.914). Following propensity matching, withholding angiotensin-converting enzyme inhibitors or angiotensin-2 receptor blockers did not demonstrate a protective effect against the development of postoperative acute kidney injury (OR (95%CI) 0.89 (0.58-1.34); p = 0.567). |
X Demographics
The data shown below were collected from the profiles of 183 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 64 | 35% |
| United States | 14 | 8% |
| Australia | 5 | 3% |
| Mexico | 4 | 2% |
| Canada | 3 | 2% |
| Italy | 3 | 2% |
| Spain | 3 | 2% |
| Ireland | 3 | 2% |
| Sweden | 2 | 1% |
| Other | 21 | 11% |
| Unknown | 61 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 99 | 54% |
| Practitioners (doctors, other healthcare professionals) | 47 | 26% |
| Scientists | 22 | 12% |
| Science communicators (journalists, bloggers, editors) | 14 | 8% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 119 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 119 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 15% |
| Student > Master | 17 | 14% |
| Student > Bachelor | 15 | 13% |
| Other | 14 | 12% |
| Student > Ph. D. Student | 8 | 7% |
| Other | 14 | 12% |
| Unknown | 33 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 65 | 55% |
| Agricultural and Biological Sciences | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 2% |
| Business, Management and Accounting | 2 | 2% |
| Chemistry | 2 | 2% |
| Other | 7 | 6% |
| Unknown | 38 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2023.
All research outputs
#368,352
of 25,782,917 outputs
Outputs from Anaesthesia
#165
of 5,158 outputs
Outputs of similar age
#7,789
of 340,813 outputs
Outputs of similar age from Anaesthesia
#5
of 78 outputs
Altmetric has tracked 25,782,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,158 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,813 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.