| Title |
Long Noncoding RNAs in Cancer: From Function to Translation
|
|---|---|
| Published in |
Trends in Cancer, October 2015
|
| DOI | 10.1016/j.trecan.2015.08.010 |
| Pubmed ID | |
| Authors |
Anirban Sahu, Udit Singhal, Arul M. Chinnaiyan |
| Abstract |
While our understanding of the molecular mechanisms underlying cancer has significantly improved, most of our knowledge focuses on protein-coding genes that make up a fraction of the genome. Recent studies have uncovered thousands of long noncoding RNAs (lncRNAs) that populate the cancer genome. A subset of these molecules shows striking cancer- and lineage-specific expression patterns, suggesting they may be potential drivers of cancer biology and have utility as clinical biomarkers. Here, we discuss emerging modalities of lncRNA biology and their interplay with cancer-associated concepts, including epigenetic regulation, DNA damage and cell cycle control, microRNA silencing, signal transduction pathways, and hormone-driven disease. Additionally, we highlight the translational impact of lncRNAs, tools for their mechanistic investigation, and directions for future lncRNA research. |
X Demographics
The data shown below were collected from the profiles of 68 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 18 | 26% |
| United Kingdom | 4 | 6% |
| Italy | 3 | 4% |
| France | 3 | 4% |
| Germany | 3 | 4% |
| Netherlands | 3 | 4% |
| Saudi Arabia | 2 | 3% |
| Chile | 1 | 1% |
| Mexico | 1 | 1% |
| Other | 7 | 10% |
| Unknown | 23 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 49% |
| Scientists | 29 | 43% |
| Science communicators (journalists, bloggers, editors) | 5 | 7% |
| Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Brazil | 1 | <1% |
| Sweden | 1 | <1% |
| India | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 156 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 25% |
| Researcher | 32 | 20% |
| Student > Master | 19 | 12% |
| Student > Bachelor | 13 | 8% |
| Professor > Associate Professor | 10 | 6% |
| Other | 23 | 14% |
| Unknown | 26 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 29% |
| Agricultural and Biological Sciences | 40 | 24% |
| Medicine and Dentistry | 26 | 16% |
| Immunology and Microbiology | 5 | 3% |
| Neuroscience | 4 | 2% |
| Other | 12 | 7% |
| Unknown | 29 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2021.
All research outputs
#1,031,396
of 25,432,721 outputs
Outputs from Trends in Cancer
#94
of 841 outputs
Outputs of similar age
#14,812
of 286,976 outputs
Outputs of similar age from Trends in Cancer
#13
of 25 outputs
Altmetric has tracked 25,432,721 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 841 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,976 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.