| Title |
Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer
|
|---|---|
| Published in |
Nature Genetics, February 2016
|
| DOI | 10.1038/ng.3503 |
| Pubmed ID | |
| Authors |
Hikmat A Al-Ahmadie, Gopa Iyer, Byron H Lee, Sasinya N Scott, Rohit Mehra, Aditya Bagrodia, Emmet J Jordan, Sizhi Paul Gao, Ricardo Ramirez, Eugene K Cha, Neil B Desai, Emily C Zabor, Irina Ostrovnaya, Anuradha Gopalan, Ying-Bei Chen, Samson W Fine, Satish K Tickoo, Anupama Gandhi, Joseph Hreiki, Agnès Viale, Maria E Arcila, Guido Dalbagni, Jonathan E Rosenberg, Bernard H Bochner, Dean F Bajorin, Michael F Berger, Victor E Reuter, Barry S Taylor, David B Solit |
| Abstract |
Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration. |
X Demographics
The data shown below were collected from the profiles of 150 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 55 | 37% |
| India | 9 | 6% |
| Spain | 6 | 4% |
| Turkey | 3 | 2% |
| Canada | 3 | 2% |
| Brazil | 2 | 1% |
| Mexico | 2 | 1% |
| United Kingdom | 2 | 1% |
| Australia | 2 | 1% |
| Other | 13 | 9% |
| Unknown | 53 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 101 | 67% |
| Scientists | 27 | 18% |
| Practitioners (doctors, other healthcare professionals) | 17 | 11% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
| Unknown | 2 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 93 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 23% |
| Student > Ph. D. Student | 17 | 18% |
| Student > Postgraduate | 10 | 11% |
| Student > Bachelor | 7 | 7% |
| Professor | 5 | 5% |
| Other | 17 | 18% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 34% |
| Biochemistry, Genetics and Molecular Biology | 23 | 24% |
| Agricultural and Biological Sciences | 11 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Chemical Engineering | 1 | 1% |
| Other | 5 | 5% |
| Unknown | 20 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 95. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2024.
All research outputs
#454,879
of 25,746,891 outputs
Outputs from Nature Genetics
#912
of 7,615 outputs
Outputs of similar age
#7,886
of 313,865 outputs
Outputs of similar age from Nature Genetics
#21
of 62 outputs
Altmetric has tracked 25,746,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,615 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,865 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.