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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Porphyrin–phospholipid liposomes permeabilized by near-infrared light
|
|---|---|
| Published in |
Nature Communications, April 2014
|
| DOI | 10.1038/ncomms4546 |
| Pubmed ID | |
| Authors |
Kevin A. Carter, Shuai Shao, Matthew I. Hoopes, Dandan Luo, Bilal Ahsan, Vladimir M. Grigoryants, Wentao Song, Haoyuan Huang, Guojian Zhang, Ravindra K. Pandey, Jumin Geng, Blaine A. Pfeifer, Charles P. Scholes, Joaquin Ortega, Mikko Karttunen, Jonathan F. Lovell |
| Abstract |
The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential to selectively enhance localized delivery. Here we describe liposomes doped with porphyrin-phospholipid that are permeabilized directly by near-infrared light. Molecular dynamics simulations identified a novel light-absorbing monomer esterified from clinically approved components predicted and experimentally demonstrated to give rise to a more stable porphyrin bilayer. Light-induced membrane permeabilization is enabled with liposomal inclusion of 10 molar % porphyrin-phospholipid and occurs in the absence of bulk or nanoscale heating. Liposomes reseal following laser exposure and permeability is modulated by varying porphyrin-phospholipid doping, irradiation intensity or irradiation duration. Porphyrin-phospholipid liposomes demonstrate spatial control of release of entrapped gentamicin and temporal control of release of entrapped fluorophores following intratumoral injection. Following systemic administration, laser irradiation enhances deposition of actively loaded doxorubicin in mouse xenografts, enabling an effective single-treatment antitumour therapy. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 57% |
| Korea, Republic of | 1 | 14% |
| Ireland | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 57% |
| Members of the public | 1 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Ireland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 213 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 26% |
| Researcher | 34 | 16% |
| Student > Master | 31 | 14% |
| Student > Doctoral Student | 13 | 6% |
| Student > Bachelor | 13 | 6% |
| Other | 33 | 15% |
| Unknown | 36 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 49 | 23% |
| Engineering | 25 | 12% |
| Agricultural and Biological Sciences | 21 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Biochemistry, Genetics and Molecular Biology | 14 | 6% |
| Other | 46 | 21% |
| Unknown | 47 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 135. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2023.
All research outputs
#263,346
of 23,114,117 outputs
Outputs from Nature Communications
#3,986
of 47,688 outputs
Outputs of similar age
#2,391
of 226,369 outputs
Outputs of similar age from Nature Communications
#33
of 476 outputs
Altmetric has tracked 23,114,117 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,688 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,369 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 476 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.