Title |
Directed vaccination against pneumococcal disease
|
---|---|
Published in |
Proceedings of the National Academy of Sciences of the United States of America, June 2016
|
DOI | 10.1073/pnas.1603007113 |
Pubmed ID | |
Authors |
Yi Li, Andrew Hill, Marie Beitelshees, Shuai Shao, Jonathan F Lovell, Bruce A Davidson, Paul R Knight, Anders P Hakansson, Blaine A Pfeifer, Charles H Jones |
Abstract |
Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of disease transition from bacterial carriage to infection with the pneumococcus serving as a model organism. Using conserved surface proteins highly expressed during virulent transition, the vaccine mounts an immune response specifically against disease-causing bacterial populations without affecting carriage. Aided by a delivery technology capable of multivalent surface display, which can be adapted easily to a changing clinical picture, results include complete protection against the development of pneumonia and sepsis during animal challenge experiments with multiple, highly variable, and clinically relevant pneumococcal isolates. The approach thus offers a unique and dynamic treatment option readily adaptable to other commensal pathogens. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 11% |
Italy | 1 | 11% |
United Kingdom | 1 | 11% |
United States | 1 | 11% |
Unknown | 5 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Scientists | 4 | 44% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
United States | 1 | 2% |
Norway | 1 | 2% |
Vietnam | 1 | 2% |
Unknown | 38 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 24% |
Researcher | 9 | 21% |
Other | 3 | 7% |
Student > Master | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 7 | 17% |
Unknown | 8 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 19% |
Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Medicine and Dentistry | 6 | 14% |
Immunology and Microbiology | 6 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 10% |
Unknown | 10 | 24% |