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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma
|
|---|---|
| Published in |
Nature Cell Biology, April 2014
|
| DOI | 10.1038/ncb2956 |
| Pubmed ID | |
| Authors |
Kunyoo Shin, Agnes Lim, Justin I. Odegaard, Jared D. Honeycutt, Sally Kawano, Michael H. Hsieh, Philip A. Beachy |
| Abstract |
Understanding how malignancies arise within normal tissues requires identification of the cancer cell of origin and knowledge of the cellular and tissue dynamics of tumour progression. Here we examine bladder cancer in a chemical carcinogenesis model that mimics muscle-invasive human bladder cancer. With no prior bias regarding genetic pathways or cell types, we prospectively mark or ablate cells to show that muscle-invasive bladder carcinomas arise exclusively from Sonic hedgehog (Shh)-expressing stem cells in basal urothelium. These carcinomas arise clonally from a single cell whose progeny aggressively colonize a major portion of the urothelium to generate a lesion with histological features identical to human carcinoma in situ. Shh-expressing basal cells within this precursor lesion become tumour-initiating cells, although Shh expression is lost in subsequent carcinomas. We thus find that invasive carcinoma is initiated from basal urothelial stem cells but that tumour cell phenotype can diverge significantly from that of the cancer cell of origin. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| Sweden | 1 | 10% |
| United Kingdom | 1 | 10% |
| France | 1 | 10% |
| Spain | 1 | 10% |
| Unknown | 3 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Scientists | 2 | 20% |
| Science communicators (journalists, bloggers, editors) | 2 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Germany | 2 | <1% |
| France | 1 | <1% |
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 197 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 22% |
| Researcher | 45 | 22% |
| Student > Master | 21 | 10% |
| Student > Bachelor | 18 | 9% |
| Professor | 9 | 4% |
| Other | 37 | 18% |
| Unknown | 32 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 33% |
| Biochemistry, Genetics and Molecular Biology | 46 | 22% |
| Medicine and Dentistry | 37 | 18% |
| Immunology and Microbiology | 6 | 3% |
| Chemistry | 4 | 2% |
| Other | 10 | 5% |
| Unknown | 35 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 87. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2015.
All research outputs
#409,071
of 22,754,104 outputs
Outputs from Nature Cell Biology
#215
of 3,818 outputs
Outputs of similar age
#3,894
of 226,533 outputs
Outputs of similar age from Nature Cell Biology
#1
of 56 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,818 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,533 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.