Title |
A New Mouse Model for Female Genital Schistosomiasis
|
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Published in |
PLoS Neglected Tropical Diseases, May 2014
|
DOI | 10.1371/journal.pntd.0002825 |
Pubmed ID | |
Authors |
Monica L. Richardson, Chi-Ling Fu, Luke F. Pennington, Jared D. Honeycutt, Justin L. Odegaard, Yi-Ju Hsieh, Olfat Hammam, Simon L. Conti, Michael H. Hsieh |
Abstract |
Over 112 million people worldwide are infected with Schistosoma haematobium, one of the most prevalent schistosome species affecting humans. Female genital schistosomiasis (FGS) occurs when S. haematobium eggs are deposited into the female reproductive tract by adult worms, which can lead to pelvic pain, vaginal bleeding, genital disfigurement and infertility. Recent evidence suggests co-infection with S. haematobium increases the risks of contracting sexually transmitted diseases such as HIV. The associated mechanisms remain unclear due to the lack of a tractable animal model. We sought to create a mouse model conducive to the study of immune modulation and genitourinary changes that occur with FGS. |
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Geographical breakdown
Country | Count | As % |
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United States | 3 | 30% |
United Kingdom | 2 | 20% |
Unknown | 5 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 60% |
Scientists | 2 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
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Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 14 | 23% |
Student > Ph. D. Student | 8 | 13% |
Student > Master | 8 | 13% |
Other | 6 | 10% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 13% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 3 | 5% |
Other | 4 | 7% |
Unknown | 18 | 30% |