Title |
Obesity associated with increased brain age from midlife
|
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Published in |
Neurobiology of Aging, July 2016
|
DOI | 10.1016/j.neurobiolaging.2016.07.010 |
Pubmed ID | |
Authors |
Lisa Ronan, Aaron F. Alexander-Bloch, Konrad Wagstyl, Sadaf Farooqi, Carol Brayne, Lorraine K. Tyler, Cam-CAN, Paul C. Fletcher |
Abstract |
Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area. Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated increase of brain age of 10 years. There were no similar body mass index-related changes in cortical parameters. This study suggests that at a population level, obesity may increase the risk of neurodegeneration. |
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Mexico | 6 | 2% |
Iran, Islamic Republic of | 4 | 1% |
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Belgium | 3 | <1% |
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Other | 20 | 7% |
Unknown | 176 | 58% |
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Practitioners (doctors, other healthcare professionals) | 21 | 7% |
Scientists | 19 | 6% |
Science communicators (journalists, bloggers, editors) | 5 | 2% |
Mendeley readers
Geographical breakdown
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Sweden | 1 | <1% |
Nigeria | 1 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Unknown | 379 | 99% |
Demographic breakdown
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Student > Ph. D. Student | 42 | 11% |
Student > Master | 38 | 10% |
Researcher | 35 | 9% |
Student > Doctoral Student | 22 | 6% |
Other | 48 | 13% |
Unknown | 116 | 30% |
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Neuroscience | 41 | 11% |
Psychology | 36 | 9% |
Agricultural and Biological Sciences | 18 | 5% |
Nursing and Health Professions | 18 | 5% |
Other | 39 | 10% |
Unknown | 128 | 33% |