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Obesity associated with increased brain age from midlife

Overview of attention for article published in Neurobiology of Aging, July 2016
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1490

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 4,437)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
152 news outlets
blogs
5 blogs
twitter
302 X users
patent
2 patents
facebook
20 Facebook pages
googleplus
10 Google+ users
reddit
2 Redditors
video
2 YouTube creators

Citations

dimensions_citation
180 Dimensions

Readers on

mendeley
383 Mendeley
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Title
Obesity associated with increased brain age from midlife
Published in
Neurobiology of Aging, July 2016
DOI 10.1016/j.neurobiolaging.2016.07.010
Pubmed ID
Authors

Lisa Ronan, Aaron F. Alexander-Bloch, Konrad Wagstyl, Sadaf Farooqi, Carol Brayne, Lorraine K. Tyler, Cam-CAN, Paul C. Fletcher

Abstract

Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area. Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated increase of brain age of 10 years. There were no similar body mass index-related changes in cortical parameters. This study suggests that at a population level, obesity may increase the risk of neurodegeneration.

X Demographics

X Demographics

The data shown below were collected from the profiles of 302 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 383 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 <1%
Nigeria 1 <1%
Switzerland 1 <1%
Canada 1 <1%
Unknown 379 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 82 21%
Student > Ph. D. Student 42 11%
Student > Master 38 10%
Researcher 35 9%
Student > Doctoral Student 22 6%
Other 48 13%
Unknown 116 30%
Readers by discipline Count As %
Medicine and Dentistry 103 27%
Neuroscience 41 11%
Psychology 36 9%
Agricultural and Biological Sciences 18 5%
Nursing and Health Professions 18 5%
Other 39 10%
Unknown 128 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1490. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2024.
All research outputs
#8,061
of 25,658,139 outputs
Outputs from Neurobiology of Aging
#1
of 4,437 outputs
Outputs of similar age
#91
of 380,855 outputs
Outputs of similar age from Neurobiology of Aging
#1
of 78 outputs
Altmetric has tracked 25,658,139 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,437 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,855 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.