Title |
Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine - Volume 23, Number 8—August 2017 - Emerging Infectious Diseases journal - CDC
|
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Published in |
Emerging Infectious Diseases, August 2017
|
DOI | 10.3201/eid2308.161582 |
Pubmed ID | |
Authors |
Gavin G. Rutledge, Ian Marr, G. Khai Lin Huang, Sarah Auburn, Jutta Marfurt, Mandy Sanders, Nicholas J. White, Matthew Berriman, Chris I. Newbold, Nicholas M. Anstey, Thomas D. Otto, Ric N. Price |
Abstract |
Plasmodium malariae is the only human malaria parasite species with a 72-hour intraerythrocytic cycle and the ability to persist in the host for life. We present a case of a P. malariae infection with clinical recrudescence after directly observed administration of artemether/lumefantrine. By using whole-genome sequencing, we show that the initial infection was polyclonal and the recrudescent isolate was a single clone present at low density in the initial infection. Haplotypic analysis of the clones in the initial infection revealed that they were all closely related and were presumably recombinant progeny originating from the same infective mosquito bite. We review possible explanations for the P. malariae treatment failure and conclude that a 3-day artemether/lumefantrine regimen is suboptimal for this species because of its long asexual lifecycle. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 55% |
Japan | 1 | 9% |
Australia | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 45% |
Scientists | 3 | 27% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 18% |
Student > Ph. D. Student | 10 | 16% |
Student > Master | 8 | 13% |
Student > Doctoral Student | 5 | 8% |
Lecturer | 5 | 8% |
Other | 14 | 23% |
Unknown | 9 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 32% |
Medicine and Dentistry | 12 | 19% |
Agricultural and Biological Sciences | 9 | 15% |
Arts and Humanities | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 3 | 5% |
Unknown | 14 | 23% |