| Title |
MERS-CoV Antibody Responses 1 Year after Symptom Onset, South Korea, 2015 - Volume 23, Number 7—July 2017 - Emerging Infectious Diseases journal - CDC
|
|---|---|
| Published in |
Emerging Infectious Diseases, July 2017
|
| DOI | 10.3201/eid2307.170310 |
| Pubmed ID | |
| Authors |
Pyoeng Gyun Choe, R.A.P.M. Perera, Wan Beom Park, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Long Wei Ronald Ko, Sang Won Park, Nam-Joong Kim, Eric H.Y. Lau, Leo L.M. Poon, Malik Peiris, Myoung-don Oh |
| Abstract |
We investigated the kinetics of the Middle East respiratory syndrome coronavirus (MERS-CoV) neutralizing and spike protein antibody titers over the course of 1 year in 11 patients who were confirmed by reverse transcription PCR to have been infected during the outbreak in South Korea in 2015. Robust antibody responses were detected in all survivors who had severe disease; responses remained detectable, albeit with some waning, for <1 year. The duration of viral RNA detection (but not viral load) in sputum significantly correlated with the antibody response magnitude. The MERS S1 ELISA antibody titers correlated well with the neutralizing antibody response. Antibody titers in 4 of 6 patients who had mild illness were undetectable even though most had evidence of pneumonia. This finding implies that MERS-CoV seroepidemiologic studies markedly underestimate the extent of mild and asymptomatic infection. Obtaining convalescent-phase plasma with high antibody titers to treat MERS will be challenging. |
X Demographics
The data shown below were collected from the profiles of 38 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 16% |
| United Kingdom | 4 | 11% |
| Saudi Arabia | 3 | 8% |
| Oman | 2 | 5% |
| Norway | 1 | 3% |
| Portugal | 1 | 3% |
| Mexico | 1 | 3% |
| Peru | 1 | 3% |
| Netherlands | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 16 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 84% |
| Scientists | 4 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 217 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 217 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 46 | 21% |
| Student > Master | 26 | 12% |
| Student > Ph. D. Student | 18 | 8% |
| Student > Bachelor | 17 | 8% |
| Other | 12 | 6% |
| Other | 44 | 20% |
| Unknown | 54 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 21% |
| Immunology and Microbiology | 37 | 17% |
| Biochemistry, Genetics and Molecular Biology | 21 | 10% |
| Agricultural and Biological Sciences | 13 | 6% |
| Veterinary Science and Veterinary Medicine | 6 | 3% |
| Other | 28 | 13% |
| Unknown | 67 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 195. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2022.
All research outputs
#206,030
of 25,703,943 outputs
Outputs from Emerging Infectious Diseases
#349
of 9,781 outputs
Outputs of similar age
#4,287
of 324,917 outputs
Outputs of similar age from Emerging Infectious Diseases
#6
of 121 outputs
Altmetric has tracked 25,703,943 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,781 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.7. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.