Title |
Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016 - Volume 23, Number 7—July 2017 - Emerging Infectious Diseases journal - CDC
|
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Published in |
Emerging Infectious Diseases, July 2017
|
DOI | 10.3201/eid2307.161608 |
Pubmed ID | |
Authors |
Paul J. Steptoe, Janet T. Scott, Julia M. Baxter, Craig K. Parkes, Rahul Dwivedi, Gabriela Czanner, Matthew J. Vandy, Fayiah Momorie, Alimamy D. Fornah, Patrick Komba, Jade Richards, Foday Sahr, Nicholas A.V. Beare, Malcolm G. Semple |
Abstract |
We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%-85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%-87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%-16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%-25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 21 | 33% |
United States | 12 | 19% |
Venezuela, Bolivarian Republic of | 1 | 2% |
Belgium | 1 | 2% |
Switzerland | 1 | 2% |
Netherlands | 1 | 2% |
Sierra Leone | 1 | 2% |
Italy | 1 | 2% |
France | 1 | 2% |
Other | 2 | 3% |
Unknown | 22 | 34% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 43 | 67% |
Practitioners (doctors, other healthcare professionals) | 11 | 17% |
Scientists | 9 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 22% |
Researcher | 8 | 16% |
Other | 4 | 8% |
Student > Ph. D. Student | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 9 | 18% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 24% |
Nursing and Health Professions | 6 | 12% |
Agricultural and Biological Sciences | 3 | 6% |
Social Sciences | 3 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 6 | 12% |
Unknown | 19 | 37% |