Title |
Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003–2013 - Volume 23, Number 11—November 2017 - Emerging Infectious Diseases journal - CDC
|
---|---|
Published in |
Emerging Infectious Diseases, November 2017
|
DOI | 10.3201/eid2311.161214 |
Pubmed ID | |
Authors |
Michihiko Goto, Jennifer S. McDanel, Makoto M. Jones, Daniel J. Livorsi, Michael E. Ohl, Brice F. Beck, Kelly K. Richardson, Bruce Alexander, Eli N. Perencevich |
Abstract |
Bacteremia caused by gram-negative bacteria is associated with serious illness and death, and emergence of antimicrobial drug resistance in these bacteria is a major concern. Using national microbiology and patient data for 2003-2013 from the US Veterans Health Administration, we characterized nonsusceptibility trends of community-acquired, community-onset; healthcare-associated, community-onset; and hospital-onset bacteremia for selected gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, and Acinetobacter spp.). For 47,746 episodes of bacteremia, the incidence rate was 6.37 episodes/10,000 person-years for community-onset bacteremia and 4.53 episodes/10,000 patient-days for hospital-onset bacteremia. For Klebsiella spp., P. aeruginosa, and Acinetobacter spp., we observed a decreasing proportion of nonsusceptibility across nearly all antimicrobial drug classes for patients with healthcare exposure; trends for community-acquired, community-onset isolates were stable or increasing. The role of infection control and antimicrobial stewardship efforts in inpatient settings in the decrease in drug resistance rates for hospital-onset isolates needs to be determined. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 63% |
Saudi Arabia | 1 | 13% |
Australia | 1 | 13% |
Unknown | 1 | 13% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 75% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 4 | 19% |
Student > Bachelor | 4 | 19% |
Researcher | 3 | 14% |
Student > Master | 2 | 10% |
Student > Doctoral Student | 1 | 5% |
Other | 4 | 19% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 48% |
Veterinary Science and Veterinary Medicine | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Environmental Science | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 24% |