| Title |
Yersinia pestis Survival and Replication in Potential Ameba Reservoir - Volume 24, Number 2—February 2018 - Emerging Infectious Diseases journal - CDC
|
|---|---|
| Published in |
Emerging Infectious Diseases, February 2018
|
| DOI | 10.3201/eid2402.171065 |
| Pubmed ID | |
| Authors |
David W. Markman, Michael F. Antolin, Richard A. Bowen, William H. Wheat, Michael Woods, Mercedes Gonzalez-Juarrero, Mary Jackson |
| Abstract |
Plague ecology is characterized by sporadic epizootics, then periods of dormancy. Building evidence suggests environmentally ubiquitous amebae act as feral macrophages and hosts to many intracellular pathogens. We conducted environmental genetic surveys and laboratory co-culture infection experiments to assess whether plague bacteria were resistant to digestion by 5 environmental ameba species. First, we demonstrated that Yersinia pestis is resistant or transiently resistant to various ameba species. Second, we showed that Y. pestis survives and replicates intracellularly within Dictyostelium discoideum amebae for ˃48 hours postinfection, whereas control bacteria were destroyed in <1 hour. Finally, we found that Y. pestis resides within ameba structures synonymous with those found in infected human macrophages, for which Y. pestis is a competent pathogen. Evidence supporting amebae as potential plague reservoirs stresses the importance of recognizing pathogen-harboring amebae as threats to public health, agriculture, conservation, and biodefense. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 63% |
| United Kingdom | 3 | 10% |
| Australia | 1 | 3% |
| Canada | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Unknown | 5 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 53% |
| Scientists | 10 | 33% |
| Practitioners (doctors, other healthcare professionals) | 3 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 15% |
| Student > Bachelor | 8 | 15% |
| Student > Ph. D. Student | 6 | 12% |
| Researcher | 5 | 10% |
| Student > Doctoral Student | 4 | 8% |
| Other | 12 | 23% |
| Unknown | 9 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 21% |
| Immunology and Microbiology | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Medicine and Dentistry | 5 | 10% |
| Engineering | 3 | 6% |
| Other | 10 | 19% |
| Unknown | 10 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 133. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2022.
All research outputs
#307,188
of 25,168,110 outputs
Outputs from Emerging Infectious Diseases
#453
of 9,683 outputs
Outputs of similar age
#7,263
of 451,947 outputs
Outputs of similar age from Emerging Infectious Diseases
#6
of 122 outputs
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We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.