Title |
Use of Bead-Based Serologic Assay to Evaluate Chikungunya Virus Epidemic, Haiti - Volume 24, Number 6—June 2018 - Emerging Infectious Diseases journal - CDC
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Published in |
Emerging Infectious Diseases, June 2018
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DOI | 10.3201/eid2406.171447 |
Pubmed ID | |
Authors |
Eric W. Rogier, Delynn M. Moss, Kimberly E. Mace, Michelle Chang, Samuel E. Jean, Stevan M. Bullard, Patrick J. Lammie, Jean Frantz Lemoine, Venkatachalam Udhayakumar |
Abstract |
The index case of chikungunya virus (CHIKV) in Haiti was reported during early 2014; the vector, the pervasive Aedes aegypti mosquito, promoted rapid spread throughout the country. During December 2014-February 2015, we collected blood samples from 4,438 persons at 154 sites (62 urban, 92 rural) throughout Haiti and measured CHIKV IgG by using a multiplex bead assay. Overall CHIKV seroprevalence was 57.9%; differences between rural (mean 44.9%) and urban (mean 78.4%) areas were pronounced. Logistic modeling identified the urban environment as a strong predictor of CHIKV exposure (adjusted odds ratio 3.34, 95% CI 2.38-4.69), and geographic elevation provided a strong negative correlation. We observed no correlation between age and antibody positivity or titer. Our findings demonstrated through serologic testing the recent and rapid dissemination of the arbovirus throughout the country. These results show the utility of serologic data to conduct epidemiologic studies of quickly spreading mosquitoborne arboviruses. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
Canada | 1 | 14% |
Ecuador | 1 | 14% |
Mozambique | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Scientists | 1 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 14% |
Student > Doctoral Student | 8 | 14% |
Other | 5 | 9% |
Researcher | 5 | 9% |
Student > Bachelor | 4 | 7% |
Other | 8 | 14% |
Unknown | 19 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Agricultural and Biological Sciences | 7 | 12% |
Nursing and Health Professions | 6 | 11% |
Medicine and Dentistry | 5 | 9% |
Immunology and Microbiology | 3 | 5% |
Other | 9 | 16% |
Unknown | 20 | 35% |