Title |
Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone - Volume 24, Number 8—August 2018 - Emerging Infectious Diseases journal - CDC
|
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Published in |
Emerging Infectious Diseases, August 2018
|
DOI | 10.3201/eid2408.171367 |
Pubmed ID | |
Authors |
Patrick J. Howlett, Anna R. Walder, Durodami R. Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N’jai, Colin S. Brown, Foday Sahr, Foday Sesay, Jonathon M. Read, Paul J. Steptoe, Nicholas A.V. Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F. Deen, Tom Solomon, Malcolm G. Semple, Janet T. Scott |
Abstract |
We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions. Of brain computed tomography scans of 17 patients, 3 showed cerebral and/or cerebellar atrophy and 2 confirmed strokes. Sixteen patients required mental health followup; psychiatric disorders were diagnosed in 5. The 10 patients who experienced greatest disability had co-existing physical and mental health conditions. EVD survivors may have ongoing central and peripheral nervous system disorders, including previously unrecognized migraine headaches and stroke. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 22 | 37% |
United States | 13 | 22% |
Canada | 2 | 3% |
Spain | 1 | 2% |
South Sudan | 1 | 2% |
Switzerland | 1 | 2% |
Australia | 1 | 2% |
Trinidad and Tobago | 1 | 2% |
United Arab Emirates | 1 | 2% |
Other | 1 | 2% |
Unknown | 16 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 38 | 63% |
Practitioners (doctors, other healthcare professionals) | 13 | 22% |
Scientists | 6 | 10% |
Science communicators (journalists, bloggers, editors) | 3 | 5% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 86 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 27% |
Student > Master | 13 | 15% |
Student > Bachelor | 8 | 9% |
Student > Doctoral Student | 6 | 7% |
Student > Ph. D. Student | 4 | 5% |
Other | 13 | 15% |
Unknown | 19 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 19% |
Nursing and Health Professions | 6 | 7% |
Immunology and Microbiology | 5 | 6% |
Social Sciences | 5 | 6% |
Psychology | 4 | 5% |
Other | 18 | 21% |
Unknown | 32 | 37% |