Title |
Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi
|
---|---|
Published in |
BMC Microbiology, March 2012
|
DOI | 10.1186/1471-2180-12-44 |
Pubmed ID | |
Authors |
Zhiming Ouyang, Sukanya Narasimhan, Girish Neelakanta, Manish Kumar, Utpal Pal, Erol Fikrig, Michael V Norgard |
Abstract |
The maintenance of Borrelia burgdorferi in its complex tick-mammalian enzootic life cycle is dependent on the organism's adaptation to its diverse niches. To this end, the RpoN-RpoS regulatory pathway in B. burgdorferi plays a central role in microbial survival and Lyme disease pathogenesis by up- or down-regulating the expression of a number of virulence-associated outer membrane lipoproteins in response to key environmental stimuli. Whereas a number of studies have reported on the expression of RpoS and its target genes, a more comprehensive understanding of when activation of the RpoN-RpoS pathway occurs, and when induction of the pathway is most relevant to specific stage(s) in the life cycle of B. burgdorferi, has been lacking. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 16% |
Researcher | 7 | 14% |
Student > Ph. D. Student | 6 | 12% |
Student > Master | 6 | 12% |
Professor > Associate Professor | 3 | 6% |
Other | 7 | 14% |
Unknown | 13 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 24% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Medicine and Dentistry | 6 | 12% |
Immunology and Microbiology | 6 | 12% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 4% |
Unknown | 15 | 30% |